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Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice
He, Baixuan1; Zheng, Minying1; Liu, Qiang2; Shi, Zhe2; Long, Simei1; Lu, Xilin1; Pei, Zhong1; Yuan, Ti-Fei3; Su, Huanxing2; Yao, Xiaoli1
2018-02
Source PublicationMOLECULAR NEUROBIOLOGY
ISSN0893-7648
Volume55Issue:2Pages:1703-1713
Abstract

Alzheimer's disease (AD) is characterized by progressive neuronal degeneration and pathological accumulation of amyloid plaques in the brain. It has been proposed that the prion-like spreading of amyloid beta (A beta) protein could contribute to the progression of the disease. Olfactory bulb (OB) is one of the earliest brain regions affected in AD and olfaction is easily impaired prior to cognitive symptoms. However, it remains unclear whether A beta accumulation in the OB would spread along olfactory projections to other connected brain regions and trigger further neurodegeneration. In the present study, we experimentally injected recombinant human A beta 1-42 (monomers and oligomers, respectively) into the mouse OB and tracked the spreading of A beta to connected brain regions over 3 days. The results showed that both A beta monomers and oligomers were rapidly and readily transferred from the injection site to interconnected brain regions in a neural connection manner and triggered neuronal apoptosis in the affected brain regions. Oligomeric A beta 1-42 spread more efficiently and induced more neuronal apoptosis in the affected brain regions compared to monomeric A beta 1-42. Therefore, the study provides evidence that A beta peptides can transfer via neural connections and the pattern of A beta peptide spreading provides understanding to manage AD.

KeywordAlzheimer's Disease Oligomers Olfactory Pathway Neural Connections Apoptosis
DOI10.1007/s12035-017-0446-1
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000425624000066
PublisherHUMANA PRESS INC
The Source to ArticleWOS
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, and Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological DiseasesThe First Affiliated Hospital, Sun Yat-Sen UniversityGuangzhouChina
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.School of Psychology, Nanjing Normal University, Nanjing, China
Recommended Citation
GB/T 7714
He, Baixuan,Zheng, Minying,Liu, Qiang,et al. Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice[J]. MOLECULAR NEUROBIOLOGY,2018,55(2):1703-1713.
APA He, Baixuan.,Zheng, Minying.,Liu, Qiang.,Shi, Zhe.,Long, Simei.,...&Yao, Xiaoli.(2018).Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice.MOLECULAR NEUROBIOLOGY,55(2),1703-1713.
MLA He, Baixuan,et al."Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice".MOLECULAR NEUROBIOLOGY 55.2(2018):1703-1713.
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