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Rhythmic Low-field magnetic stimulation may improve depression by increasing brain derived neurotropic factor
Xiao L1; Correll CU2; Feng L1; Xiang YT3; Feng Y1; Hu CQ1; Li R1,4; Wang G1
2018
Source PublicationCNS spectrums.
ISSN1092-8529
Volume24Issue:3Pages:313-321
Abstract

Background

Low-field magnetic stimulation (LFMS) has mood-elevating effect, and the increase of brain-derived neurotrophic factor (BDNF) is associated with antidepressant treatment. We evaluated the effects and association with BDNF of rhythmic LFMS in the treatment of major depressive disorder (MDD).

Methods

A total of 22 MDD patients were randomized to rhythmic alpha stimulation (RAS) or rhythmic delta stimulation (RDS), with 5 sessions per week, lasting for 6 weeks. Outcomes assessments included the 17-item Hamilton Depression Rating Scale (HAMD–17), the Hamilton Anxiety Rating Scale (HAMA), and the Clinical Global Impressions–Severity scale (CGI–S) at baseline and at weeks 1, 2, 3, 4, and 6. Serum BDNF level was measured at baseline and at weeks 2, 4, and 6.

Results

HAMD–17, HAMA, and CGI–S scores were significantly reduced with both RAS and RDS. RAS patients had numerically greater reductions in HAMD–17 scores than RDS patients (8.9 ± 7.4 vs. 6.2 ± 6.2, effect size [ES]=0.40), while RDS patients had greater improvement in HAMA scores (8.2 ± 8.0 vs. 5.3 ± 5.8, ES=0.42). RAS was associated with clinically relevant advantages in response (54.5% vs. 18.2%, number-needed-to-treat [NNT]=3) and remission (36.4% vs. 9.1%, NNT=4). BDNF increased significantly during the 6-week study period (p<0.05), with greater increases in RAS at weeks 4 and 6 (ES=0.66—0.76) and statistical superiority at week 2 (p=0.034, ES=1.23). Baseline BDNF in the 8 responders (24.8±9.0 ng/ml) was lower than in the 14 nonresponders (31.1±7.3 ng/ml, p=0.083, ES=–0.79), and BDNF increased more in responders (8.9±7.8 ng/ml) than in nonresponders (1.8±3.5 ng/ml, p=0.044). The change in BDNF at week 2 was the most strongly predicted response (p=0.016).

Conclusions

Rhythmic LFMS was effective for MDD. BDNF may moderate/mediate the efficacy of LFMS.

KeywordMajor Depressive Disorder Rhythmic Magnetic Stimulation Brain-derived Neurotrophic Factor Moderator Mediator
DOIhttps://doi.org/10.1017/S1092852917000670
Indexed BySCIE
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000475688400005
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing,China.
2.Department of Psychiatry,The Zucker Hillside Hospital,Northwell Health,Glen Oaks,New York,United States.
3.Unit of Psychiatry, Faculty of Health Sciences,University of Macau,Macao SAR,China.
4.Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China
Recommended Citation
GB/T 7714
Xiao L,Correll CU,Feng L,et al. Rhythmic Low-field magnetic stimulation may improve depression by increasing brain derived neurotropic factor[J]. CNS spectrums.,2018,24(3):313-321.
APA Xiao L.,Correll CU.,Feng L.,Xiang YT.,Feng Y.,...&Wang G.(2018).Rhythmic Low-field magnetic stimulation may improve depression by increasing brain derived neurotropic factor.CNS spectrums.,24(3),313-321.
MLA Xiao L,et al."Rhythmic Low-field magnetic stimulation may improve depression by increasing brain derived neurotropic factor".CNS spectrums. 24.3(2018):313-321.
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