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JOONG SUP SHIM ASSOCIATE PROFESSOR
Title : ASSOCIATE PROFESSOR
Institute: Faculty of Health Sciences
Research Fields: My lab is studying major tumor suppressor genes, including p53, PTEN, RB1, BRCA1, ARID1A, and SMAD4, and is expanding to newly identified tumor suppressors. We have established isogenic cell pairs for the tumor suppressor genes and actively working on identifying synthetic lethality partners using chemical and genetic screenings.
Contact email: jsshim@um.edu.mo
Notes: --
JOONG SUP SHIM

Research Contents

Synthetic lethality is a genetic interaction where a single gene deficiency is tolerable for cell viability while the combination of deficiencies in two genes leads to cell death. The concept of the synthetic lethality has been widely exploited in cancer research field because a large portion of cancer has loss-of-function mutations in tumor suppressor genes. Synthetic lethality utilizes the mutations in tumor suppressor genes as a mark for selectivity of anticancer drugs. Pharmacological or genetic perturbation of a synthetic lethality partner of a tumor suppressor will cause selective lethality of the cancer cells that carry the tumor suppressor mutation. As it provides a strong cancer cell selectivity, synthetic lethality is one of core approaches for cancer precision medicine.

My lab is studying major tumor suppressor genes, including p53, PTEN, RB1, BRCA1, ARID1A, and SMAD4, and is expanding to newly identified tumor suppressors. We have established isogenic cell pairs for the tumor suppressor genes and actively working on identifying synthetic lethality partners using chemical and genetic screenings.

Honors & Rewards

2011-06-25 Young Investigator Award in “2011 KSEA/KASBP Northeast Regional Conference and Bio Fair”, Edison, NJ, USA
2004-05-25 Best Poster Award in “The 61st Annual Meeting 2004” of the Korean Society for Biochemistry and Molecular Biology, Seoul, Korea
2001-10-18 Best Poster Award in “The Annual Meeting 2001” of the Korean Society for Biochemistry and Molecular Biology, Seoul, Korea

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