My research interest mainly focus on the mechanisms of transcriptional regulation of gene expression and gene expression regulatory network. I am also interested in understanding the mechanisms of human diseases such as cancer by exploring the aberrant gene expression associated with these diseases. For instance, the current on-going projects focus on transcriptional factors such as BRCA1 and CtBP by illustrating their important role in alteration cell metabolism which may associates with cancer development. The research strategy relies on both high throughput screening technologies such as NGS, gene expression microarray etc and individual gene study. The conclusion from cell based studies will be validated in other relevant model system such engineered mouse models.