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LEE MING YUEN PROFESSOR
Title : PROFESSOR
Institute: Institute of Chinese Medical Sciences
Research Fields: Biochemistry of cancer, cardiovascular and neurodegenerative diseases;Molecular pharmacology of Chinese medicine;Systems biology: genome, transcriptome, proteome and protein interaction network
Contact email: simonlee@um.edu.mo
Notes: Professor
LEE MING YUEN

Research Contents

 

•Biochemistry of cancer, cardiovascular and neurodegenerative diseases.
•Molecular pharmacology of Chinese medicine.
•Systems biology: genome, transcriptome, proteome and protein interaction network

Biography

•Founder member of BioEdu programme, funded by Education and Youth Affairs Bureau, Macau SAR Government. (2007-present).
•Vice President of Director Board, Macao Association for Promotion of Science and Technology (2013-present). ?
•Macao-PISA 2008 Science Education Study for Education and Youth Affairs Bureau, Macau SAR Government.
•Member of Scientific Review Committee, Macao Regional Science Fair (affiliation of Intel International Science and Engineering Fair) funded by Education and Youth Affairs Bureau, Macau SAR Government. (2010-present).
•Technical expert of an ISO/IEC 17025 accreditation assessment. Innovation and Technology Commission (ITC), Hong Kong SAR Government (2012-2015).
•Board Member of International Society for Chinese Medicine (2012-present).
•Member of TCM Pharmacology Committee, Chinese Medicine Pharmacological Society World Federation of Chinese Medicine Societies (2012-present).
•Member of Organizing Committee, Distinguished Chinese Scientists Public Lecture Series (2008-present).
•Exhibition of “Application of zebrafish in drug screening for treatment of cardiovascular diseases” which is selected as popular research projects in an activity entitled “Science is by your side: Vote for Your Favourite Local Science Researches”, for Macao Science Center.
•Reviewer editor of Frontiers in Cardiovascular and Smooth Muscle Pharmacology (2010-2013), editorial board member of Journal of Biochemistry – Molecular Biology in the Post-genomic Era (2010-2013) and Chinese Medicine (2013-2015)
•Add-hoc reviewers of over 20 international referred journals (e.g Angiogenesis, Journal of Cellular and Molecular Medicine, European Journal of Medicinal Chemistry, Cell Proliferation, PLoS One, Cancer Science, Caner Investigation, Virology Journal, Journal of Cellular Biochemistry, Basic & Clinical Pharmacology & Toxicology, Journal of Pharmacology and Experimental Therapeutics, Chinese Medicine, Evidence Based Complementary and Alternative Medicine).

Honors & Rewards

2011-09-22

Project

_ 基於斑馬魚平臺結合多種模型系統研究三七花皂?促血管新生作用及機制, (國家自然科學基金-海外及港澳學者合作研究基金, 2014-1015, P.I.)
_ Novel anti-Parkinson’s leads: pharmacological elucidation of multi-targeted neuroprotections by sunitinib analogs including the natural components from Chinese medicine, , funded by Research Grants Council Earmarked Grants in Hong Kong, 2014 – 2016, Co.I.
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_ A study on synergistic bone anabolic effects of a combination use of Alendronate and Herba Epimedii in treating osteoporosis of ovariactomized rats, funded by Health and Medical Research Fund, 2012 – 2014, Co.I.
_ Unexpected anti-Parkinson’s neuroprotective and its molecular targets of Sunitinib, a clinical used anti-cancer drug, funded by National Natural Science Foundation, 2013 – 2015, Co.I.
_ Characterization, structural optimization and mechanistic study of the neuroprotective components from Chinese medicine for minimising and treating Parkinson’s disease complications, funded by Science and Technology Development Fund, 2012 – 2015, P.I.
_ Mechanistic studies of active compounds-combination from Chinese medicine for minimising and treating cardio-cerebrovascular complications, funded by Science and Technology Development Fund, 2011 – 2014, P.I.
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_ Establishment of a DNA sequencing and bioinformatics analysis platform for genome and transcriptome analysis, funded by Science and Technology Development Fund, 2010 – 2013, P.I.
_ Characterization and mechanistic study of the bioactive components from selected Chinese medicine for proangiogenic and neuroprotective activities, funded by Science and Technology Development Fund, 2008 – 2011, P.I.
_ The theoretical pharmacology study on Chinese Herbs: Tianma and Gouteng (天麻、鉤藤歸經理論研究) funded by National Natural Science Foundation, 2009 – 2012, Co.I.
_ The discovery and mechanism study of angiogenesis inhibitors from three Salvia herbal medicine funded by National Natural Science Foundation, 2010 – 2013, Co.I.
_ A study on molecular mechanism of anti-influenza virus effect of Chinese Medicine with second-generation DNA sequencing technology funded by Open Research Grant-Guangzhou Institute of Respiratory Disease, 2010 – 2012, Co.I.
_ Study on the active ingredients and mechanism of action of Chinese medicine on treatment of atherosclerosis, funded by Science and Technology Development Fund, 2005 – 2008, P.I. with Prof YiTao Wang.
_ Characterization and mechanistic study of the bioactive components from TCM for the anti-proliferative Effect on Human Hepatoma Cells in vitro and in Vivo, funded by Science and Technology Development Fund, 2006 – 2007, P.I.
_ Characterization and mechanistic study of the bioactive components from selected Chinese medicine for anti-breast cancer activities using system biology approach, funded by Science and Technology Development Fund, 2008 – 2011, Co.I.
_ Study of the effects of Herba Epimedii (Yinyanghuo) and Fructus Ligustri Lucidi (Nvzhenzi) on bone and mineral metabolism, funded by Research Grants Council Earmarked Grants in Hong Kong, 2004 – 2006, Co.I.
_ Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis, funded by Research Grants Council Earmarked Grants in Hong Kong, 2003 – 2006, Co.I.

Research Outputs

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