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Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:507/10 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways Journal article
REDOX BIOLOGY, 2017,Volume: 11
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Wang, Xiaotong;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Wan, Jian-Bo;  Lee, Simon Ming Yuen;  Liu, Kechun;  He, Chengwei
Favorite | View/Download:29/0 | TC[WOS]:71 TC[Scopus]:0 | Submit date:2018/10/30
Berberine  Hormesis  Neuroprotection  Pc12 Cells  Zebrafish  
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Ma, Lijuan;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Lee, Simon Ming Yuen;  Liu, Kechun;  Wan, Jian-Bo;  He, Chengwei
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Discovery, synthesis, and functional characterization of a novel neuroprotective natural product from the fruit of alpinia oxyphylla for use in Parkinson's disease through LC/MS-based multivariate data analysis-guided fractionation Journal article
Journal of Proteome Research, 2016,Volume: 15,Issue: 8,Page: 2595-2606
Authors:  Guohui Li;  Zaijun Zhang;  Quan Quan;  Renwang Jiang;  Samuel S.W. Szeto;  Shuai Yuan;  Wing-tak Wong;  Herman H. C. Lam;  Simon Ming-Yuen Lee;  Ivan K. Chu
Favorite | View/Download:9/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/11/06
Natural Products  Neuroprotective  Nrf2  Parkinson's Disease  Proteomics  
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3 β pathways Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2015,Volume: 170,Page: 8-15
Authors:  Lun Qing Zhang;  Fei Sa;  Cheong Meng Chong;  Ying Wang;  Zhong Yan Zhou;  Raymond Chuen Chung Chang;  Shun Wan Chan;  Pui Man Hoi;  Simon Ming Yuen Lee
Favorite | View/Download:4/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2020/04/15
6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson׳s Disease  Schisantherin a  
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β Journal article
Journal of Molecular Neuroscience, 2015,Volume: 57,Issue: 4,Page: 561
Authors:  Hu S.;  Cui W.;  Zhang Z.;  Mak S.;  Xu D.;  Li G.;  Hu Y.;  Wang Y.;  Lee M.;  Tsim K.W.;  Han Y.
Favorite | View/Download:6/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/10/30
6OHDA  GSK3β  Indirubin-3-oxime  MEF2D  Neuroprotection  Parkinson’s disease  
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease Journal article
Free Radical Biology and Medicine, 2015,Volume: 84,Page: 331
Authors:  Zaijun Zhang;  Guohui Li;  Samuel S.W. Szeto;  Cheong Meng Chong;  Quan Quan;  Chen Huang;  Wei Cui;  Baojian Guo;  Yuqiang Wang;  Yifan Han;  K.W. Michael Siu;  Simon Ming Yuen Lee;  Ivan K. Chu
Favorite | View/Download:9/0 | TC[WOS]:68 TC[Scopus]:0 | Submit date:2018/10/30
Anti-inflammation  Freeradicals  Neuroprotection  Nrf2 Nf-κb  Parkinsondisease  Proteomics  
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo Journal article
Biological and Pharmaceutical Bulletin, 2014,Volume: 37,Issue: 2,Page: 274-285
Authors:  Guo B.;  Xu D.;  Duan H.;  Du J.;  Zhang Z.;  Lee S.M.;  Wang Y.
Favorite | View/Download:8/0 | TC[WOS]:27 TC[Scopus]:0 | Submit date:2018/11/06
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (Mptp)  6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson's Disease  Tetramethylpyrazine Nitrone  
The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis Journal article
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2014,Volume: 9,Issue: 2,Page: 245-258
Authors:  Xu, DP;  Duan, HW;  Zhang, ZJ;  Cui, W;  Wang, L;  Sun, YW;  Lang, M;  Hoi, PM;  Han, YF;  Wang, YQ;  Lee, SM
Favorite | View/Download:5/0 | TC[WOS]:21 TC[Scopus]:0 | Submit date:2020/04/15
Mitochondrial-dependent Apoptosis  Parkinson’s Disease  Mptp  Dopaminergic Neuron  
A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways Journal article
Neurochemistry International, 2014,Volume: 78,Page: 76
Authors:  Xu D.-P.;  Zhang K.;  Zhang Z.-J.;  Sun Y.-W.;  Guo B.-J.;  Wang Y.-Q.;  Hoi P.-M.;  Han Y.-F.;  Lee S.M.-Y.
Favorite | View/Download:7/0 | TC[WOS]:13 TC[Scopus]:0 | Submit date:2018/10/30
6-Hydroxydopamine  Neuroinflammation  Neuroprotection  Tetramethylpyrazine derivative