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Imaging of macrophage mitochondria dynamics in vivo reveals cellular activation phenotype for diagnosis Journal article
Theranostics, 2020,Volume: 10,Issue: 7,Page: 2897-2917
Authors:  Li,Yue;  He,Yuan;  Miao,Kai;  Zheng,Ying;  Deng,Chuxia;  Liu,Tzu Ming
Favorite | View/Download:1/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
In vivo imaging  Liposome  Macrophage  Mitochondria  Multiphoton microscopy  
Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
STEM CELL REPORTS, 2019,Volume: 13,Issue: 2,Page: 338-351
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng;  Yiqi Yang;  Shreyas Lingadahalli;  Edwin Cheung;  Gang Li;  Weiwei Liu;  Jianbo Wan;  Yang Zhao;  Guokai Chen
Favorite | View/Download:16/0 | TC[WOS]:1 TC[Scopus]:0 | Submit date:2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation  
A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Xinhua Zhou;  Anqi Wang;  Liang Wang;  Jianhua Yin;  Li Wang;  Lijun Di;  Maggie Pui-Man Hoi;  Luchen Shan;  Xu Wu;  Yuqiang Wang
Favorite | View/Download:11/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2020/05/21
Danshensu  Tetramethylpyrazine  Breast Cancer  Resistance  Glycolysis  P-glycoprotein  
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer Journal article
THERANOSTICS, 2019,Volume: 9,Issue: 1,Page: 179-195
Authors:  Jing Li;  Dongdong Cheng;  Miaoxin Zhu;  Huajian Yu;  Zhen Pan;  Lei Liu;  Qin Geng;  Hongyu Pan;  Mingxia Yan;  Ming Yao
Favorite | View/Download:14/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2020/03/11
Deubiquitinating Enzyme  Otub2  Nsclc  Warburg Effect  U2af2  
The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism Journal article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018,Volume: 37
Authors:  Feng, Yixiao;  Wu, Mingjun;  Li, Shuman;  He, Xiaoqian;  Tang, Jun;  Peng, Weiyan;  Zeng, Beilei;  Deng, Chuxia;  Ren, Guosheng;  Xiang, Tingxiu
Favorite | View/Download:10/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2019/01/17
CYGB  GLUT1  HXK2  p53  Breast cancer  Metabolism  Glycolysis  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite | View/Download:18/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | View/Download:28/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/10/30
Dichloroacetophenone  Epidermal Growth Factor Receptor  Tyrosine Kinase Inhibitor  Synergism  Hypoxia  Oxidative Phosphorylation  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite | View/Download:21/0 | TC[WOS]:6 TC[Scopus]:0 | Submit date:2018/10/30
Aerobic Glycolysis  Azd7545  Dichloroacetate  Lc-ms/ms  Pyruvate Dehydrogenase Kinases  Cancer Metabolism  
Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors Journal article
DRUG DISCOVERY TODAY, 2018,Volume: 23,Issue: 7,Page: 1407-1415
Authors:  Zhang, Shao-Lin;  He, Yun;  Tam, Kin Yip
Favorite | View/Download:20/0 | TC[WOS]:13 TC[Scopus]:0 | Submit date:2018/10/30
Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4 Journal article
ONCOGENESIS, 2018,Volume: 7
Authors:  Wang, Li;  Li, Jing-jiag;  Guo, Li-yu;  Li, Peipei;  Zhao, Zhiqiang;  Zhou, Haisheng;  Di, Li-jun
Favorite | View/Download:22/0 | TC[WOS]:18 TC[Scopus]:0 | Submit date:2018/10/30