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Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance Journal article
MBIO, 2019,Volume: 10,Issue: 1
Authors:  Sang Hu Kim;  Kali R. Iyer;  Lakhansing Pardeshi;  José F. Muñoz;  Nicole Robbins;  Christina A. Cuomo;  Koon Ho Wong;  Leah E. Cowen
Favorite | View/Download:11/0 | TC[WOS]:13 TC[Scopus]:0 | Submit date:2020/06/12
Antifungal Drug Resistance  Candida Albicans  Candida Auris  Cdr1  Developmental Program  Emerging Pathogen  Fungal Morphogenesis  Fungal Pathogen  Hsp90  Transcriptional Program  
Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery Journal article
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018,Volume: 11
Authors:  Li, Ting;  Jiang, Hu-Lin;  Tong, Yun-Guang;  Lu, Jin-Jian
Favorite | View/Download:24/0 | TC[WOS]:8 TC[Scopus]:0 | Submit date:2018/10/30
Hsp90 Chaperone Machinery  Cdc37  Kinase Client  Protein Interaction  
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space Journal article
PLOS GENETICS, 2018,Volume: 14,Issue: 3
Authors:  Veri, Amanda O.;  Miao, Zhengqiang;  Shapiro, Rebecca S.;  Tebbji, Faiza;  O'Meara, Teresa R.;  Kim, Sang Hu;  Colazo, Juan;  Tan, Kaeling;  Vyas, Valmik K.;  Whiteway, Malcolm;  Robbins, Nicole;  Wong, Koon Ho;  Cowen, Leah E.
Favorite | View/Download:46/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2018/10/30
1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy Journal article
ADVANCED MATERIALS, 2017,Volume: 29,Issue: 40
Authors:  Yang, Yu;  Zhu, Wenjun;  Dong, Ziliang;  Chao, Yu;  Xu, Lai;  Chen, Meiwan;  Liu, Zhuang
Favorite | View/Download:29/0 | TC[WOS]:94 TC[Scopus]:0 | Submit date:2018/10/30
Cancer Theranostics  Coordination-polymer Nanofibers  Drug Delivery  Gambogic Acid  Low-temperature Photothermal Therapy  
Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017,Volume: 330,Page: 65-73
Authors:  Li, Ting;  Chen, Xin;  Dai, Xiao-Yang;  Wei, Bin;  Weng, Qin-Jie;  Chen, Xiuping;  Ouyang, De-Fang;  Yan, Ru;  Huang, Zhang-Jian;  Jiang, Hu-Lin;  Zhu, Hong;  Lu, Jin-Jian
Favorite | View/Download:18/0 | TC[WOS]:13 TC[Scopus]:0 | Submit date:2018/10/30
Everolimus  Platycodin d  Hsp90  Cdc37  Egfr  Igf1r  
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol Journal article
International Journal of Oncology, 2016,Volume: 49,Issue: 4,Page: 1576-1588
Authors:  Xu S.-W.;  Law B.Y.K.;  Mok S.W.F.;  Leung E.L.H.;  Fan X.X.;  Coghi P.S.;  Zeng W.;  Leung C.-H.;  Ma D.-L.;  Liu L.;  Wong V.K.W.
Favorite | View/Download:9/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/11/06
Autophagy  Calcium  Celastrol  Epidermal Growth Factor Receptor  Gefitinib-resistant Lung Cancer  
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans Journal article
Nature Communications, 2016,Volume: 7
Authors:  Michelle D. Leach;  Rhys A. Farrer;  Kaeling Tan;  Zhengqiang Miao;  Louise A. Walker;  Christina A. Cuomo;  Robert T. Wheeler;  Alistair J. P. Brown;  Koon Ho Wong;  Leah E. Cowen
Favorite | View/Download:9/0 | TC[WOS]:34 TC[Scopus]:0 | Submit date:2019/01/16
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodeling and chromatin architecture in Candida albicans Journal article
NATURE COMMUNICATIONS, 2016,Volume: 7
Authors:  Michelle D. Leach;  Rhys A. Farrer;  Kaeling Tan;  Zhengqiang Miao;  Louise A. Walker;  Christina A. Cuomo;  Robert T. Wheeler;  Alistair J. P. Brown;  Koon Ho Wong;  Leah E. Cowen
Favorite | View/Download:7/0 | TC[WOS]:34 TC[Scopus]:0 | Submit date:2019/01/21
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine Journal article
Oncotarget, 2015,Volume: 6,Issue: 32,Page: 32790
Authors:  Jiang Q.-W.;  Cheng K.-J.;  Mei X.-L.;  Qiu J.-G.;  Zhang W.-J.;  Xue Y.-Q.;  Qin W.-M.;  Yang Y.;  Zheng D.-W.;  Chen Y.;  Wei M.-N.;  Zhang X.;  Lv M.;  Chen M.-W.;  Wei X.;  Shi Z.
Favorite | View/Download:11/0 | TC[WOS]:45 TC[Scopus]:0 | Submit date:2018/10/30
Cancer  Celastrol  Combination Therapy  Triptolide  
Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir Journal article
Journal of the National Cancer Institute, 2012,Volume: 104,Issue: 20,Page: 1576-1590
Authors:  Shim J.S.;  Rao R.;  Beebe K.;  Neckers L.;  Han I.;  Nahta R.;  Liu J.O.
Favorite | View/Download:5/0 | TC[WOS]:52 TC[Scopus]:0 | Submit date:2019/01/15