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Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Sun,Xianding;  Zhou,Yang;  Zhang,Ruobin;  Wang,Zuqiang;  Xu,Meng;  Zhang,Dali;  Huang,Junlan;  Luo,Fengtao;  Li,Fangfang;  Ni,Zhenhong;  Zhou,Siru;  Chen,Hangang;  Chen,Shuai;  Chen,Liang;  Du,Xiaolan;  Chen,Bo;  Huang,Haiyang;  Liu,Peng;  Yin,Liangjun;  Qiu,Juhui;  Chen,Di;  Deng,Chuxia;  Xie,Yangli;  Luo,Lingfei;  Chen,Lin
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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
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BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis Journal article
Advanced Science, 2020,Volume: 7,Issue: 6
Authors:  Chen,Qiang;  Lei,Josh Haipeng;  Bao,Jiaolin;  Wang,Haitao;  Hao,Wenhui;  Li,Licen;  Peng,Cheng;  Masuda,Takaaki;  Miao,Kai;  Xu,Jun;  Xu,Xiaoling;  Deng,Chu Xia
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ATM-AMPK-DRP1  BRCA1  inflammasomes  mitochondrial dynamics  mitophagy  
Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Zihao Wang;  Ke-Gang Linghu;  Yuanjia Hu;  Huali Zuo;  Hao Yi;  Shi-Hang Xiong;  Jinjian Lu;  Ging Chan;  Hua Yu;  Run-Yue Huang
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Rheumatoid Arthritis  Network Pharmacology  Traditional Chinese Medicine  Huayu-qiangshen-tongbi Formula  In Vitro Validation  
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
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Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Metformin protects PC12 cells and hippocampal neurons from H2O (2)-induced oxidative damage through activation of AMPK pathway Journal article
JOURNAL OF CELLULAR PHYSIOLOGY, 2019,Volume: 234,Issue: 9,Page: 16619-16629
Authors:  Xia Zhao;  Zhiwen Zeng;  Uma Gaur;  Jiankang Fang;  Tangming Peng;  Shuai Li;  Wenhua Zheng
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Aging  Amp-activated Protein Kinase  Hydrogen Peroxide  Metformin  Pc12 Cells  
Nuclear localization of Desmoplakin and its involvement in telomere maintenance Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019,Volume: 15,Issue: 11,Page: 2350-2362
Authors:  Peipei Li;  Yuan Meng;  Yuan Wang;  Jingjing Li;  Manting Lam;  Li Wang;  Li-jun Di
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Crispr Bioid Telomere Dsp  
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions Journal article
Autophagy, 2019,Volume: 15,Issue: 8,Page: 1356-1375
Authors:  Kim,Tae Sung;  Jin,Yeung Bae;  Kim,Yi Sak;  Kim,Sup;  Kim,Jin Kyung;  Lee,Hye Mi;  Suh,Hyun Woo;  Choe,Jin Ho;  Kim,Young Jae;  Koo,Bon Sang;  Kim,Han Na;  Jung,Mingyu;  Lee,Sang Hee;  Kim,Don Kyu;  Chung,Chaeuk;  Son,Ji Woong;  Min,Jung Joon;  Kim,Jin Man;  Deng,Chu Xia;  Kim,Hyun Seok;  Lee,Sang Rae;  Jo,Eun Kyeong
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autophagy  mitochondrial homeostasis  Mycobacterium tuberculosis  PPARA  SIRT3  
Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells Journal article
STEM CELLS, 2019,Volume: 37,Issue: 8,Page: 1030-1041
Authors:  Carlos Godoy‐Parejo;  Chunhao Deng;  Weiwei Liu;  Guokai Chen
Favorite  |  View/Download:11/0  |  Submit date:2020/05/21
Hesc  Cell Survival  Cell Adhesion  Focal Adhesion  Niche  Individualization  Insulin  Integrin  Caspase  Igf  Akt  
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 Journal article
NATURE METHODS, 2019,Volume: 16,Issue: 8,Page: 722–730
Authors:  Gigi C. G. Choi;  Peng Zhou;  Chaya T. L. Yuen;  Becky K. C. Chan;  Feng Xu;  Siyu Bao;  Hoi Yee Chu;  Dawn Thean;  Kaeling Tan;  Koon Ho Wong;  Zongli Zheng;  Alan S. L. Wong
Favorite  |  View/Download:13/0  |  Submit date:2020/05/21