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Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells Journal article
Stem Cell Reports, 2018,Volume: 11,Issue: 6,Page: 1347-1356
Authors:  Meng Y.;  Ren Z.;  Xu F.;  Zhou X.;  Song C.;  Wang V.Y.-F.;  Liu W.;  Lu L.;  Thomson J.A.;  Chen G.
Favorite  |  View/Download:13/0  |  Submit date:2019/01/15
cell differentiation  cell survival  human pluripotent stem cell  kinase inhibitor  nicotinamide  
Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway Journal article
Scientific Reports, 2018,Volume: 8,Issue: 1
Authors:  Cai F.-F.;  Wu R.;  Song Y.-N.;  Xiong A.-Z.;  Chen X.-L.;  Yang M.-D.;  Yang L.;  Hu Y.;  Sun M.-Y.;  Su S.-B.
Favorite  |  View/Download:18/0  |  Submit date:2018/12/28
A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2 Journal article
CHEMICAL SCIENCE, 2018,Volume: 9,Issue: 43
Authors:  Vellaisamy, Kasipandi;  Li, Guodong;  Wang, Wanhe;  Leung, Chung-Hang;  Ma, Dik-Lung
Favorite  |  View/Download:9/0  |  Submit date:2019/01/17
Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response Journal article
INORGANIC CHEMISTRY, 2018,Volume: 57,Issue: 22,Page: 14023-14026
Authors:  Kang, Tian-Shu;  Ko, Chung-Nga;  Zhang, Jia-Tong;  Wu, Chun;  Wong, Chun-Yuen;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:16/0  |  Submit date:2019/01/17
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:17/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:27/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal Growth Factor Receptor  Tyrosine Kinase Inhibitor  Synergism  Hypoxia  Oxidative Phosphorylation  
Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors Journal article
BIOTECHNOLOGY AND BIOENGINEERING, 2018,Volume: 115,Issue: 11,Page: 2828-2843
Authors:  Fu, Afu;  Peh, Yu Ming;  Ngan, Weida;  Wei, Na;  Luo, Kathy Qian
Favorite  |  View/Download:10/0  |  Submit date:2019/01/17
antimetastasis drug discovery  fluorescence resonance energy transfer  PI3K  AKT pathway  three dimensional tumor spheroids  zebrafish xenograft tumor model  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:22/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 13,Page: 1769-1781
Authors:  Baek,Hye Jung;  Kim,Sun Eui;  Kim,Jong Kwang;  Shin,Dong Hoon;  Kim,Tae Hyun;  Kim,Kwang Gi;  Deng,Chu Xia;  Kim,Sang Soo
Favorite  |  View/Download:0/0  |  Submit date:2020/09/16
AKT  BRCA1  MK-2206  Precision medicine  
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 40,Page: 13091-13095
Authors:  Yang, Guan-Jun;  Wang, Wanhe;  Mok, Simon Wing Fai;  Wu, Chun;  Law, Betty Yuen Kwan;  Miao, Xiang-Min;  Wu, Ke-Jia;  Zhong, Hai-Jing;  Wong, Chun-Yuen;  Wong, Vincent Kam Wai;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:39/0  |  Submit date:2018/10/30
Drug Discovery  Epigenetics  Medicinal Chemistry  Triple-negative Breast Cancer