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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:8/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia) Journal article
ARCHIVES OF TOXICOLOGY, 2019,Volume: 93,Issue: 6,Page: 1745-1767
Authors:  Qiwen Liao;  Guiyi Gong;  Terence C. W. Poon;  Irene L. Ang;  Kate M. K. Lei;  Shirley Weng In Siu;  Clarence Tsun Ting Wong;  Gandhi Rádis-Baptista;  Simon Ming-Yuen Lee
Favorite  |  View/Download:226/0  |  Submit date:2020/01/16
Cnidaria  Neuroprotection  Proteomic  Transcriptomic  Venom-derived Peptide  Zoantharian  
Aurone derivatives as Vps34 inhibitors that modulate autophagy Journal article
ACTA PHARMACEUTICA SINICA B, 2019,Volume: 9,Issue: 3,Page: 537-544
Authors:  Guodong Li;  Joshua William Boyle;  Chung-Nga Ko;  Wu Zeng;  Vincent Kam Wai Wong;  Jian-Bo Wan;  Philip Wai Hong Chan;  Dik-Lung Ma;  Chung-Hang Leung
Favorite  |  View/Download:10/0  |  Submit date:2020/03/24
Autophagy  Natural Products  Vps34  Inhibitor  Structure-based Virtualscreening  Vesicle Trafficking  Heart Or Liver Damage  Aurone Derivative  
Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats Journal article
FOOD AND CHEMICAL TOXICOLOGY, 2019,Volume: 129,Page: 97-107
Authors:  Wenwen Zhao;  Yuan Yuan;  Haiyu Zhao;  Yantao Han;  Xiuping Chen
Favorite  |  View/Download:12/0  |  Submit date:2020/01/07
Diabetic Vascular Injury  Salvia Miltiorrhiza Bunge  Radix Puerariae  Oxidative Stress  Cell Adhesion Molecules  
A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019,Volume: 120,Issue: 4,Page: 5913-5922
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan;  Simon Ming‐Yuen Lee;  Guozhen Cui
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Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-gamma Dependent Regulation of NF-kappa B Journal article
FRONTIERS IN PHARMACOLOGY, 2019,Volume: 10
Authors:  Ke-Gang Linghu;  Guo-Ping Wu;  Ling-Yun Fu;  Hong Yang;  Hai-Zhi Li;  Yan Chen;  Hua Yu;  Ling Tao;  Xiang-Chun Shen
Favorite  |  View/Download:14/0  |  Submit date:2020/03/10
1,8-cineole  Human Umbilical Vein Endothelial Cell  Lipopolysaccharide  Nf-κb  Ppar-γ  
Synthesis and Evaluation of Dibenzothiophene Analogues as Pin1 Inhibitors for Cervical Cancer Therapy Journal article
ACS OMEGA, 2019,Volume: 4,Issue: 5,Page: 9228-9234
Authors:  Wu, KJ;  Liu, X;  Wong, SY;  Zhou, YY;  Ma, DL;  Leung, CH
Favorite  |  View/Download:7/0  |  Submit date:2020/03/24
A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes Journal article
CHEMICAL COMMUNICATIONS, 2019,Volume: 55,Issue: 45,Page: 6353-6356
Authors:  Wu, C;  Wu, KJ;  Liu, JB;  Zhou, XM;  Leung, CH;  Ma, DL
Favorite  |  View/Download:5/0  |  Submit date:2020/03/23
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite  |  View/Download:10/0  |  Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Inhibitory effects of anthocyanins on α-glucosidase activity Journal article
JOURNAL OF BERRY RESEARCH, 2019,Volume: 9,Issue: 1,Page: 109-123
Authors:  Zhang, Jiaojiao;  Xiao, Jianbo;  Giampieri, Francesca;  Forbes-Hernandez, Tamara Y;  Gasparrini, Massimiliano;  Afrin, Sadia;  Cianciosi, Danila;  Reboredo-Rodriguez, Patricia;  Battino, Maurizio;  Zheng, Xiaodong
Favorite  |  View/Download:7/0  |  Submit date:2020/04/27
Anthocyanins  Not Glycosylated Forms  Glycosylated Forms  Inhibitors  Α-glucosidase  Sugar Metabolism