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Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction Journal article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018,Volume: 66,Issue: 31,Page: 8307-8318
Authors:  Li, Chuwen;  Tang, Benqin;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  Su, Ziren;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:17/0  |  Submit date:2018/10/31
Pinostrobin  Parkinson's Disease  Neurotoxin  Nrf2  
Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes Journal article
JOURNAL OF FOOD BIOCHEMISTRY, 2017,Volume: 41,Issue: 6
Authors:  Zhang, Huan;  Zhou, Xuelin;  Wong, Marcus Ho-Yin;  Man, Ka-Yi;  Pin, Wing-Kwan;  Yeung, John Hok-Keung;  Kwan, Yiu-Wa;  Leung, George Pak-Heng;  Hoi, Pui-Man;  Lee, Simon Ming-Yuen;  Chan, Chi-On;  Mok, Daniel Kam-Wah;  Yu, Peter Hoi-Fu;  Chan, Shun-Wan
Favorite  |  View/Download:23/0  |  Submit date:2018/10/30
Liver  Reactive Oxygen Species  Rutaceae  Zanthoxylum Bungeanum Maxim  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:507/10  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity Journal article
Molecular Pharmaceutics, 2017,Volume: 14,Issue: 10,Page: 3331-3342
Authors:  Tongkai Chen;  Ye Li;  Chuwen Li;  Xiang Yi;  Ruibing Wang;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite  |  View/Download:14/0  |  Submit date:2018/11/06
Baicalein  Fluorescence Resonance Energy Transfer (Fret)  Micelles  Mitochondria  Multidrug Resistance-associated Protein 2 (Mrp2)  Neuroprotective Effect  
pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities Journal article
ACTA BIOMATERIALIA, 2017,Volume: 58,Page: 349-364
Authors:  Zhang, Jinming;  Li, Jingjing;  Shi, Zhi;  Yang, Yang;  Xie, Xi;  Lee, Simon MingYuen;  Wang, Yitao;  Leong, Kam W.;  Chen, Meiwan
Favorite  |  View/Download:21/0  |  Submit date:2018/10/30
Anticancer  Ph-sensitive Nanoparticle  Apoptosis  Anti-angiogenesis  Co-delivery  
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II Journal article
Oncotarget, 2016,Volume: 7,Issue: 22,Page: 32054-32064
Authors:  Wang L.;  Zhang X.;  Cui G.;  Chan J.Y.-W.;  Wang L.;  Li L.;  Shan L.;  Xu C.;  Zhang Q.;  Wang Y.;  Di L.;  Lee S.M.-Y.
Favorite  |  View/Download:9/0  |  Submit date:2018/11/06
Breast Cancer  Danshensu  Mitochondrial Complex Ii  Reactive Oxygen Species  Tetramethylpyrazine  
Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models Journal article
Free Radical Biology and Medicine, 2015,Volume: 89,Page: 1057-1066
Authors:  Cheong-Meng Chong;  Dan Ma;  Chao Zhao;  Robin J.M. Franklin;  Zhong-Yan Zhou;  Nana Ai;  Chuwen Li;  Huidong Yu;  Tingjun Hou;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite  |  View/Download:16/0  |  Submit date:2018/11/06
Mpp++++  Neurodegeneration  Rat Organotypiccerebellarcultures  Zebrafish  
Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt/Nrf2/HO-1 and calcium signalling pathways Journal article
Journal of Functional Foods, 2015,Volume: 18,Page: 213-223
Authors:  Si Wan Lei;  Guozhen Cui;  George Pak Heng Leung;  Sharon Chui Wah Luk;  Maggie Pui Man Hoi;  Liang Wang;  Gail B. Mahady;  Simon Ming Yuen Lee
Favorite  |  View/Download:10/0  |  Submit date:2018/11/06
Calcium Ion  Cardiac H9c2 Cells  Icaritin  Nf-e2-related Factor 2  Oxidative Stress  
Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury Journal article
Oxidative Medicine and Cellular Longevity, 2015,Volume: 2015
Authors:  Xinhua Zhou;  Longjun Zhu;  Liang Wang;  Baojian Guo;  Gaoxiao Zhang;  Yewei Sun;  Zaijun Zhang;  Simon Ming-Yuen Lee;  Pei Yu;  Yuqiang Wang
Favorite  |  View/Download:11/0  |  Submit date:2018/11/06
Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells Journal article
Free Radical Biology and Medicine, 2014,Volume: 74,Page: 283-293
Authors:  Chong, CM;  Shen, MY;  Zhou, ZY;  Pan, PC;  Hoi, PM;  Li, S;  Liang, W;  Ai, NN;  Zhang, LQ;  Li, CW;  Yu, HD;  Hou, TJ;  Lee, SMY
Favorite  |  View/Download:7/0  |  Submit date:2020/04/15
Parkinson Disease  Free Radicals  No  Ros  Rock  Benzofuran  Mpp++++