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Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Archives of Toxicology, 2019,Volume: 93,Issue: 1,Page: 189-206
Authors:  Liao Q.;  Li S.;  Siu S.W.I.;  Morlighem J.-E.R.L.;  Wong C.T.T.;  Wang X.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite | View/Download:18/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2019/04/04
Anti-epilepsy  Disulfide Bond  Neuroactive Peptides  Neuroprotection  Protein Docking  Voltage-gated Sodium Ion Channel Blocker  
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
Favorite | View/Download:36/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/10/30
Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes Journal article
JOURNAL OF FOOD BIOCHEMISTRY, 2017,Volume: 41,Issue: 6
Authors:  Zhang, Huan;  Zhou, Xuelin;  Wong, Marcus Ho-Yin;  Man, Ka-Yi;  Pin, Wing-Kwan;  Yeung, John Hok-Keung;  Kwan, Yiu-Wa;  Leung, George Pak-Heng;  Hoi, Pui-Man;  Lee, Simon Ming-Yuen;  Chan, Chi-On;  Mok, Daniel Kam-Wah;  Yu, Peter Hoi-Fu;  Chan, Shun-Wan
Favorite | View/Download:23/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/10/30
Liver  Reactive Oxygen Species  Rutaceae  Zanthoxylum Bungeanum Maxim  
Sailuotong Prevents Hydrogen Peroxide (H2O2)-Induced Injury in EA.hy926 Cells Journal article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017,Volume: 18,Issue: 1
Authors:  Seto, Sai Wang;  Chang, Dennis;  Ko, Wai Man;  Zhou, Xian;  Kiat, Hosen;  Bensoussan, Alan;  Lee, Simon M. Y.;  Hoi, Maggie P. M.;  Steiner, Genevieve Z.;  Liu, Jianxun
Favorite | View/Download:20/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2018/10/30
Reactive Oxygen Species  Sailuotong (Slt)  Herbal Medicine  Apoptosis  Endothelial Dysfunction  Vascular Dementia  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite | View/Download:7/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II Journal article
Oncotarget, 2016,Volume: 7,Issue: 22,Page: 32054-32064
Authors:  Wang L.;  Zhang X.;  Cui G.;  Chan J.Y.-W.;  Wang L.;  Li L.;  Shan L.;  Xu C.;  Zhang Q.;  Wang Y.;  Di L.;  Lee S.M.-Y.
Favorite | View/Download:9/0 | TC[WOS]:20 TC[Scopus]:0 | Submit date:2018/11/06
Breast Cancer  Danshensu  Mitochondrial Complex Ii  Reactive Oxygen Species  Tetramethylpyrazine  
TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Hisa Hui Ling Tseng;  Chi Teng Vong;  Yiu Wa Kwan;  Simon Ming-Yuen Lee;  Maggie Pui Man Hoi
Favorite | View/Download:6/0 | TC[WOS]:20 TC[Scopus]:0 | Submit date:2018/10/30
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3 β pathways Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2015,Volume: 170,Page: 8-15
Authors:  Lun Qing Zhang;  Fei Sa;  Cheong Meng Chong;  Ying Wang;  Zhong Yan Zhou;  Raymond Chuen Chung Chang;  Shun Wan Chan;  Pui Man Hoi;  Simon Ming Yuen Lee
Favorite | View/Download:4/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2020/04/15
6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson׳s Disease  Schisantherin a  
Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt/Nrf2/HO-1 and calcium signalling pathways Journal article
Journal of Functional Foods, 2015,Volume: 18,Page: 213-223
Authors:  Si Wan Lei;  Guozhen Cui;  George Pak Heng Leung;  Sharon Chui Wah Luk;  Maggie Pui Man Hoi;  Liang Wang;  Gail B. Mahady;  Simon Ming Yuen Lee
Favorite | View/Download:10/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2018/11/06
Calcium Ion  Cardiac H9c2 Cells  Icaritin  Nf-e2-related Factor 2  Oxidative Stress  
Cortex Fraxini (Qingpi) Protects Rat Pheochromocytoma Cells against 6-Hydroxydopamine-Induced Apoptosis Journal article
Parkinson's Disease, 2015,Volume: 2015
Authors:  Jing-Jie Li;  Shi-Ya Zhou;  Huan Zhang;  Kim-Hung Lam;  Simon Ming-Yuen Lee;  Peter Hoi-Fu Yu;  Shun-Wan Chan
Favorite | View/Download:7/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/11/06