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MLKL mediates apoptosis via a mutual regulation with PERK/eIF2α pathway in response to reactive oxygen species generation Journal article
Apoptosis, 2018,Volume: 23,Issue: 9-10,Page: 521-531
Authors:  Cao W.-X.;  Li T.;  Tang Z.-H.;  Zhang L.-L.;  Wang Z.-Y.;  Guo X.;  Su M.-X.;  Chen X.;  Lu J.-J.
Favorite | View/Download:13/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/28
Apoptosis  Chelerythrine  Eif2α  Mlkl  Ros  
Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2018,Volume: 18,Issue: 4,Page: 550-555
Authors:  Tang Z.-H.;  Su M.-X.;  Guo X.;  Jiang X.-M.;  Jia L.;  Chen X.;  Lu J.-J.
Favorite | View/Download:9/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/12/28
Azd9291  Egfr  Ire1α  Lune Cancer  Nsclc  Osimertinib  
Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line Journal article
Oncotarget, 2016,Volume: 7,Issue: 49,Page: 81598-81610
Authors:  Tang Z.-H.;  Jiang X.-M.;  Guo X.;  Fong C.M.V.;  Chen X.;  Lu J.-J.
Favorite | View/Download:11/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2018/12/28
Azd9291  Egfr  Navitoclax  Nsclc  Osimertinib  
Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells Journal article
Journal of Natural Medicines, 2015,Volume: 69,Issue: 4,Page: 522-530
Authors:  Ren G.;  Sha T.;  Guo J.;  Li W.;  Lu J.;  Chen X.
Favorite | View/Download:8/0 | TC[WOS]:25 TC[Scopus]:0 | Submit date:2018/12/28
Autophagy  Breast Cancer  Cucurbitacin b  Dna Damage  Ros  
FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion Journal article
BMC Medical Genomics, 2015,Volume: 8,Issue: 1
Authors:  Zheng Y.;  Guo J.;  Zhou J.;  Lu J.;  Chen Q.;  Zhang C.;  Qing C.;  Koeffler H.P.;  Tong Y.
Favorite | View/Download:5/0 | TC[WOS]:24 TC[Scopus]:0 | Submit date:2018/12/28
Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2014,Volume: 14,Issue: 8,Page: 1146-1153
Authors:  Guo J.;  Zhao W.;  Hao W.;  Ren G.;  Lu J.;  Chen X.
Favorite | View/Download:9/0 | TC[WOS]:25 TC[Scopus]:0 | Submit date:2018/12/28
Apoptosis  Cancer  Cucurbitacin b  Dna Damage  G2/m Arrest  Ros  
Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner Journal article
PLoS ONE, 2014,Volume: 9,Issue: 2
Authors:  Guo J.;  Wu G.;  Bao J.;  Hao W.;  Lu J.;  Chen X.
Favorite | View/Download:6/0 | TC[WOS]:40 TC[Scopus]:0 | Submit date:2018/10/30
Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway Journal article
PLOS ONE, 2013,Volume: 8,Issue: 10
Authors:  Wu, Guo-Sheng;  Song, YL (Song, Yue-Lin);  Yin, Zhi-Qi;  Guo, Jia-Jie;  Wang, Sheng-Peng;  Zhao, Wen-Wen;  Chen, Xiu-Ping;  Zhang, Qing-Wen;  Lu, Jin-Jian;  Wang, Yi-Tao
Favorite | View/Download:15/0 | TC[WOS]:28 TC[Scopus]:0 | Submit date:2018/11/01
Quinones Derived from Plant Secondary Metabolites as Anti-cancer Agents Journal article
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013,Volume: 13,Issue: 3,Page: 456-463
Authors:  Lu, Jin-Jian;  Bao, Jiao-Lin;  Wu, Guo-Sheng;  Xu, Wen-Shan;  Huang, Ming-Qing;  Chen, Xiu-Ping;  Wang, Yi-Tao
Favorite | View/Download:14/0 | TC[WOS]:63 TC[Scopus]:0 | Submit date:2018/11/01
Quinone  Secondary Metabolites  Tumor  
Biological activities and potential molecular targets of cucurbitacins: a focus on cancer Journal article
ANTI-CANCER DRUGS, 2012,Volume: 23,Issue: 8,Page: 777-787
Authors:  Chen, XP (Chen, Xiuping);  Bao, JL (Bao, Jiaolin);  Guo, JJ (Guo, Jiajie);  Ding, Q (Ding, Qian);  Lu, JJ (Lu, Jinjian);  Huang, MQ (Huang, Mingqing);  Wang, YT (Wang, Yitao)
Favorite | View/Download:7/0 | TC[WOS]:74 TC[Scopus]:0 | Submit date:2018/11/01
Cell-cycle Arrest  Cell-cycle Arrest  Bryonia-alba l  Pancreatic-cancer  Inhibitory-activity  Antitumor-activity  Signaling Pathway  Leukemia-cells  Melanoma-cells  In-vitro