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Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Sun,Xianding;  Zhou,Yang;  Zhang,Ruobin;  Wang,Zuqiang;  Xu,Meng;  Zhang,Dali;  Huang,Junlan;  Luo,Fengtao;  Li,Fangfang;  Ni,Zhenhong;  Zhou,Siru;  Chen,Hangang;  Chen,Shuai;  Chen,Liang;  Du,Xiaolan;  Chen,Bo;  Huang,Haiyang;  Liu,Peng;  Yin,Liangjun;  Qiu,Juhui;  Chen,Di;  Deng,Chuxia;  Xie,Yangli;  Luo,Lingfei;  Chen,Lin
Favorite  |  View/Download:0/0  |  Submit date:2020/09/16
Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling Journal article
Journal of Bone and Mineral Research, 2019,Volume: 34,Issue: 11,Page: 2101-2116
Authors:  Sun,Xianding;  Zhang,Ruobin;  Liu,Mi;  Chen,Hangang;  Chen,Liang;  Luo,Fengtao;  Zhang,Dali;  Huang,Junlan;  Li,Fangfang;  Ni,Zhenhong;  Qi,Huabing;  Su,Nan;  Jin,Min;  Yang,Jing;  Tan,Qiaoyan;  Du,Xiaolan;  Chen,Bo;  Huang,Haiyang;  Chen,Shuai;  Yin,Liangjun;  Xu,Xiaoling;  Deng,Chuxia;  Luo,Lingfei;  Xie,Yangli;  Chen,Lin
Favorite  |  View/Download:0/0  |  Submit date:2020/09/16
CARTILAGE-HAIR HYPOPLASIA  RMRP  SKELETAL DEVELOPMENT  WNT/Β-CATENIN  ZEBRAFISH  
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice Journal article
Journal of Cellular Physiology, 2019,Volume: 234,Issue: 1,Page: 595-605
Authors:  Wang Q.;  Tan Q.;  Xu W.;  Kuang L.;  Zhang B.;  Wang Z.;  Ni Z.;  Su N.;  Jin M.;  Li C.;  Jiang W.;  Huang J.;  Li F.;  Zhu Y.;  Chen H.;  Du X.;  Chen D.;  Deng C.;  Qi H.;  Xie Y.;  Chen L.
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Activing Receptor-like Kinases 5 (Alk5)  Matrix Degradation  Meniscal Degeneration  Transforming Growth Factor-β (Tgf-β) Signaling  
Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model Journal article
Molecular Therapy - Nucleic Acids, 2018,Volume: 13,Page: 291-302
Authors:  Luo F.;  Xie Y.;  Wang Z.;  Huang J.;  Tan Q.;  Sun X.;  Li F.;  Li C.;  Liu M.;  Zhang D.;  Xu M.;  Su N.;  Ni Z.;  Jiang W.;  Chang J.;  Chen H.;  Chen S.;  Xu X.;  Deng C.;  Wang Z.;  Du X.;  Chen L.
Favorite  |  View/Download:25/0  |  Submit date:2018/12/13
Adeno-associated Virus  Apert Syndrome  Craniosynostosis  Fgfr2  Molecular Therapy  Rnai  
Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model Journal article
Molecular Therapy - Nucleic Acids, 2018,Volume: 13,Page: 291-302
Authors:  Luo,Fengtao;  Xie,Yangli;  Wang,Zuqiang;  Huang,Junlan;  Tan,Qiaoyan;  Sun,Xianding;  Li,Fangfang;  Li,Can;  Liu,Mi;  Zhang,Dali;  Xu,Meng;  Su,Nan;  Ni,Zhenhong;  Jiang,Wanling;  Chang,Jinhong;  Chen,Hangang;  Chen,Shuai;  Xu,Xiaoling;  Deng,Chuxia;  Wang,Zhugang;  Du,Xiaolan;  Chen,Lin
Favorite  |  View/Download:0/0  |  Submit date:2020/09/16
adeno-associated virus  Apert syndrome  craniosynostosis  Fgfr2  molecular therapy  RNAi  
A novel FGFR1-binding peptide attenuates the degeneration ofarticular cartilage in adult mice Journal article
Osteoarthritis and Cartilage, 2018,Volume: 26,Issue: 12,Page: 1733-1743
Authors:  Q. Tan;  B. Chen;  Q. Wang;  W.Xu;  Y.Wang;  Z. Lin;  F.Luo;  S. Huang;  Y.Zhu;  N. Su;  M. Jin;  C.Li;  L. Kuang;  H.Qi;  Z.Ni;  Z. Wang;  X. Luo;  W. Jiang;  H. Chen;  S. Chen;  F.Li;  B. Zhang;  J. Huang;  R. Zhang;  K. Jin;  X.Xu;  C. Deng;  X.Du;  Y. Xie;  L. Chen
Favorite  |  View/Download:28/0  |  Submit date:2018/12/17
Fgfr1  Peptide  Osteoarthritis  Mice  
A novel FGFR1-binding peptide attenuates the degeneration of articular cartilage in adult mice Journal article
Osteoarthritis and Cartilage, 2018,Volume: 26,Issue: 12,Page: 1733-1743
Authors:  Tan Q.;  Chen B.;  Wang Q.;  Xu W.;  Wang Y.;  Lin Z.;  Luo F.;  Huang S.;  Zhu Y.;  Su N.;  Jin M.;  Li C.;  Kuang L.;  Qi H.;  Ni Z.;  Wang Z.;  Luo X.;  Jiang W.;  Chen H.;  Chen S.;  Li F.;  Zhang B.;  Huang J.;  Zhang R.;  Jin K.;  Xu X.;  Deng C.;  Du X.;  Xie Y.;  Chen L.
Favorite  |  View/Download:13/0  |  Submit date:2018/12/17
FGFR1  Mice  Osteoarthritis  Peptide  
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice Journal article
The Journal of Biological Chemistry, 2018
Authors:  Kai Miao;  Xin Zhang;  Sek Man Su;  Jianming Zeng;  Zebin Huang;  Un In Chan;  Xiaoling Xu;  Chu-Xia Deng
Favorite  |  View/Download:26/0  |  Submit date:2018/12/17
Fgfr3  Crispr/cas9  Protein  Targeted Correction  Off-target  Achondroplasia  Dwarfism  Genome Editing  Gene Therapy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite  |  View/Download:38/0  |  Submit date:2018/12/17
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite  |  View/Download:23/0  |  Submit date:2018/12/17