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Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-Gly374Arg mutation in achondroplasia in mice Journal article
The Journal of Biological Chemistry, 2018
Authors:  Kai Miao;  Xin Zhang;  Sek Man Su;  Jianming Zeng;  Zebin Huang;  Un In Chan;  Xiaoling Xu;  Chu-Xia Deng
Favorite | View/Download:26/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/17
Fgfr3  Crispr/cas9  Protein  Targeted Correction  Off-target  Achondroplasia  Dwarfism  Genome Editing  Gene Therapy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite | View/Download:38/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/17
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite | View/Download:24/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/12/17
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis Journal article
ONCOGENE, 2018,Volume: 37,Issue: 17,Page: 2343-2350
Authors:  Lahusen, Tyler J.;  Kim, Seung-Jin;  Miao, Kai;  Huang, Zebin;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite | View/Download:29/0 | TC[WOS]:6 TC[Scopus]:0 | Submit date:2018/10/30
SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion Journal article
CELL REPORTS, 2017,Volume: 18,Issue: 13,Page: 3155-3166
Authors:  Chen, Qiang;  Hao, Wenhui;  Xiao, Cuiying;  Wang, Ruihong;  Xu, Xiaoling;  Lu, Huiyan;  Chen, Weiping;  Deng, Chu-Xia
Favorite | View/Download:20/0 | TC[WOS]:24 TC[Scopus]:0 | Submit date:2018/10/30
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Zheng, Hongping;  Shao, Fangyuan;  Martin, Scots;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite | View/Download:19/0 | TC[WOS]:15 TC[Scopus]:0 | Submit date:2018/10/30
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells Journal article
Breast Cancer Research, 2014,Volume: 16,Issue: 3
Authors:  Vazquez-Ortiz G.;  Chisholm C.;  Xu X.;  Lahusen T.J.;  Li C.;  Sakamuru S.;  Huang R.;  Thomas C.J.;  Xia M.;  Deng C.
Favorite | View/Download:12/0 | TC[WOS]:11 TC[Scopus]:0 | Submit date:2018/12/13
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis Journal article
Cell Metabolism, 2010,Volume: 12,Issue: 3,Page: 224-236
Authors:  Kim H.-S.;  Xiao C.;  Wang R.-H.;  Lahusen T.;  Xu X.;  Vassilopoulos A.;  Vazquez-Ortiz G.;  Jeong W.-I.;  Park O.;  Ki S.H.;  Gao B.;  Deng C.-X.
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53BP1 inhibits homologous recombination in brca1-deficient cells by blocking resection of DNA breaks Journal article
Cell, 2010,Volume: 141,Issue: 2,Page: 243-254
Authors:  Bunting S.F.;  Callen E.;  Wong N.;  Chen H.-T.;  Polato F.;  Gunn A.;  Bothmer A.;  Feldhahn N.;  Fernandez-Capetillo O.;  Cao L.;  Xu X.;  Deng C.-X.;  Finkel T.;  Nussenzweig M.;  Stark J.M.;  Nussenzweig A.
Favorite | View/Download:15/0 | TC[WOS]:889 TC[Scopus]:0 | Submit date:2018/12/13
Dna  Humdisease  
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice Journal article
Journal of Clinical Investigation, 2006,Volume: 116,Issue: 7,Page: 1843-1852
Authors:  Xu X.;  Kobayashi S.;  Qiao W.;  Li C.;  Xiao C.;  Radaeva S.;  Stiles B.;  Wang R.-H.;  Ohara N.;  Yoshino T.;  LeRoith D.;  Torbenson M.S.;  Gores G.J.;  Wu H.;  Gao B.;  Deng C.-X.
Favorite | View/Download:11/0 | TC[WOS]:129 TC[Scopus]:0 | Submit date:2018/12/13