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Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 Journal article
NATURE METHODS, 2019,Volume: 16,Issue: 8,Page: 722–730
Authors:  Gigi C. G. Choi;  Peng Zhou;  Chaya T. L. Yuen;  Becky K. C. Chan;  Feng Xu;  Siyu Bao;  Hoi Yee Chu;  Dawn Thean;  Kaeling Tan;  Koon Ho Wong;  Zongli Zheng;  Alan S. L. Wong
Favorite  |  View/Download:12/0  |  Submit date:2020/05/21
Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi Journal article
FUNGAL GENETICS AND BIOLOGY, 2019,Volume: 125,Page: 28-35
Authors:  Longguang Qin;  Ang Li;  Kaeling Tan;  Shuhui Guo;  Yingying Chen;  Fang Wang;  Koon Ho Wong
Favorite  |  View/Download:7/0  |  Submit date:2020/05/21
Gene Deletion  Epitope Tagging  Selectable Markers  Plasmid Collection  Filamentous Fungi  Aspergillus  
A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe Journal article
BMC GENOMICS, 2019,Volume: 20
Authors:  Dane Vassiliadis;  Koon Ho Wong;  Alex Andrianopoulos;  Brendon J. Monahan
Favorite  |  View/Download:11/0  |  Submit date:2020/06/12
Schizosaccharomyces Pombe  Transcriptional Regulation  Carbon Metabolism  Carbon Catabolite Repression  Rst2  Rna-seq  Chip-seq Background  Tup11  Scr1  
Requirements for RNA polymerase II preinitiation complex formation in vivo Journal article
ELIFE, 2019,Volume: 8
Authors:  Natalia Petrenko;  Yi Jin;  Liguo Dong;  Koon Ho Wong;  Kevin Struhl
Favorite  |  View/Download:8/0  |  Submit date:2020/06/12
Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance Journal article
MBIO, 2019,Volume: 10,Issue: 1
Authors:  Sang Hu Kim;  Kali R. Iyer;  Lakhansing Pardeshi;  José F. Muñoz;  Nicole Robbins;  Christina A. Cuomo;  Koon Ho Wong;  Leah E. Cowen
Favorite  |  View/Download:10/0  |  Submit date:2020/06/12
Antifungal Drug Resistance  Candida Albicans  Candida Auris  Cdr1  Developmental Program  Emerging Pathogen  Fungal Morphogenesis  Fungal Pathogen  Hsp90  Transcriptional Program  
Novel variants identified in multiple sclerosis patients from southern China Journal article
Frontiers in Neurology, 2018,Volume: 9
Authors:  Wang H.;  Pardeshi L.A.;  Rong X.;  Li E.;  Wong K.H.;  Peng Y.;  Xu R.-H.
Favorite  |  View/Download:17/0  |  Submit date:2018/12/20
Human Leucocyte Antigen  Multiple Sclerosis  Single Nucleotide Polymorphism  Triobp  Whole-exome Sequencing  
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite  |  View/Download:23/0  |  Submit date:2018/12/17
Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia Journal article
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018,Volume: 293,Issue: 22,Page: 8315-8329
Authors:  Sun, Heng;  Miao, Zhengqiang;  Zhang, Xin;  Chan, Un In;  Su, Sek Man;  Guo, Sen;  Wong, Chris Koon Ho;  Xu, Xiaoling;  Deng, Chu-Xia
Favorite  |  View/Download:46/0  |  Submit date:2018/10/30
Mammary Gland  Development  Breast Cancer  Biomarker  Cell Differentiation  Stem Cells  cdh5+cell  Mammary Stem Cells (Mascs)  Single Cell Rna-seq  
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space Journal article
PLOS GENETICS, 2018,Volume: 14,Issue: 3
Authors:  Veri, Amanda O.;  Miao, Zhengqiang;  Shapiro, Rebecca S.;  Tebbji, Faiza;  O'Meara, Teresa R.;  Kim, Sang Hu;  Colazo, Juan;  Tan, Kaeling;  Vyas, Valmik K.;  Whiteway, Malcolm;  Robbins, Nicole;  Wong, Koon Ho;  Cowen, Leah E.
Favorite  |  View/Download:44/0  |  Submit date:2018/10/30
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation Journal article
NATURE COMMUNICATIONS, 2017,Volume: 8
Authors:  Xie, Jinglin L.;  Qin, Longguang;  Miao, Zhengqiang;  Grys, Ben T.;  Diaz, Jacinto De La Cruz;  Ting, Kenneth;  Krieger, Jonathan R.;  Tong, Jiefei;  Tan, Kaeling;  Leach, Michelle D.;  Ketela, Troy;  Moran, Michael F.;  Krysan, Damian J.;  Boone, Charles;  Andrews, Brenda J.;  Selmecki, Anna;  Wong, Koon Ho;  Robbins, Nicole;  Cowen, Leah E.
Favorite  |  View/Download:18/0  |  Submit date:2018/10/30