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Inhibiting β-Amyloid-Associated Alzheimer’s Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue Journal article
Journal of Molecular Neuroscience, 2015,Volume: 55,Issue: 4,Page: 1014
Authors:  Hu S.;  Wang R.;  Cui W.;  Zhang Z.;  Mak S.;  Xu D.;  Choi C.;  Tsim K.W.;  Carlier P.R.;  Lee M.;  Han Y.
Favorite  |  View/Download:2/0  |  Submit date:2018/10/30
Alzheimer’s disease  Aβ fibrils  Bis(12)-hupyridone  Cell viability  Memory impairment  Thioflavin T  
Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2009,Volume: 49,Issue: 2,Page: 410
Authors:  Yu H.;  Li W.M.;  Cheung M.C.;  Zuo Z.;  Carlier P.R.;  Gu Z.M.;  Chan K.;  Huang M.;  Wang Y.T.;  Han Y.F.
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Alzheimer's Disease  Bis(12)-hupyridone  Hplc-dad  Pharmacokinetics  
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine Journal article
Journal of Pharmaceutical and Biomedical Analysis, 2008,Volume: 46,Issue: 1,Page: 75
Authors:  Yu H.;  Li W.-M.;  Kan K.K.W.;  Ho J.M.K.;  Carlier P.R.;  Pang Y.-P.;  Gu Z.-M.;  Zhong Z.;  Chan K.;  Wang Y.-T.;  Han Y.-F.
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Ache Inhibition  Bis(12)-hupyridone  Bis(7)-tacrine  Dimer  Ionization Constant  Lipophilicity  Solubility