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A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells Journal article
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019,Volume: 120,Issue: 4,Page: 5913-5922
Authors:  Ying Zhang;  Hongkuan Deng;  Hefeng Zhou;  Yucong Lu;  Luchen Shan;  Simon Ming‐Yuen Lee;  Guozhen Cui
Favorite | View/Download:242/0 | TC[WOS]:6 TC[Scopus]:0 | Submit date:2020/01/16
Antitumor  Biotin-conjugated Adtm Analog (Baa)  Cardioprotection  Cardiotoxicity  Doxorubicin (Dox)  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite | View/Download:34/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKK beta-Dependent AMPK Activation Journal article
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018,Volume: 11
Authors:  Li, Chuwen;  Zhang, Chao;  Zhou, Hefeng;  Feng, Yu;  Tang, Fan;  Hoi, Maggie P. M.;  He, Chengwei;  Ma, Dan;  Zhao, Chao;  Lee, Simon M. Y.
Favorite | View/Download:29/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2018/10/30
Amp-activated Protein Kinase  Betulinic Acid  Calmodulin-dependent Protein Kinase Beta  Microglia Polarization  Neuroinflammation  
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 820,Page: 86-96
Authors:  Tang, Fan;  Zhou, Xinhua;  Wang, Liang;  Shan, Luchen;  Li, Chuwen;  Zhou, Hefeng;  Lee, Simon Ming-Yuen;  Hoi, Maggie Pui-Man
Favorite | View/Download:21/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/10/30
Cardioprotection  Anti-oxidative Stress  Anti-apoptosis  Autophagy Regulation  Zebrafish Cardiotoxicity  H9c2 Cardiomyocytes  
Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation Journal article
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018,Volume: 47,Issue: 5,Page: 1769-1784
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Zhang, Chao;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  He, Chengwei;  Zheng, Ying;  Lee, Simon Ming-Yuen
Favorite | View/Download:35/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/10/30
Schisantherin a  Neuroinflammation  Microglia  Nrf2  Nf-kappa b  
Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics Journal article
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2017,Volume: 31,Issue: 11
Authors:  Chan, Judy Yuet-Wa;  Zhou, Hefeng;  Kwan, Yiu Wa;  Chan, Shun Wan;  Radis-Baptista, Gandhi;  Lee, Simon Ming-Yuen
Favorite | View/Download:45/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/10/30
Acute Toxicity  Rhodamine B-crotamine  Screening Of Pharmaceuticals  Venom-derived Peptides  Zebrafish Model  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite | View/Download:7/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening Journal article
Molecular BioSystems, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:11/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/11/06
Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
MOLECULAR BIOSYSTEMS, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:5/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/07/30
The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides Journal article
Genome Biology and Evolution, 2016,Volume: 8,Issue: 9,Page: 3045-3064
Authors:  Chen Huang;  Jean-Étienne RL Morlighem;  Hefeng Zhou;  Érica P Lima;  Paula B Gomes;  Jing Cai;  Inchio Lou;  Carlos D Pérez;  Simon Ming Lee;  Gandhi Rádis-Baptista
Favorite | View/Download:8/0 | TC[WOS]:19 TC[Scopus]:0 | Submit date:2018/11/06
Hexacorallia  Molecular Toxinology  Peptide Toxin  Rna-seq  Transcriptome  Venomics  Zoanthidea