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Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice Journal article
PHYTOMEDICINE, 2009,Volume: 16,Issue: 5,Page: 426-436
Authors:  S.W. Seto;  T.Y. Lam;  H.L. Tam;  A.L.S. Au;  S.W. Chan;  J.H. Wu;  P.H.F. Yu;  G.P.H. Leung;  S.M. Ngai;  J.H.K. Yeung;  P.S. Leung;  S.M.Y. Lee;  Y.W. Kwan
Favorite | View/Download:5/0 | TC[WOS]:71 TC[Scopus]:0 | Submit date:2020/05/07
Type 2 Diabetes Mellitus  Ganoderma Lucidum  Pepck  Hmg Coa Reductase  
L-Tetrahydropalamatine Inhibits Tumor Necrosis Factor-α-Induced Monocyte-Endothelial Cell Adhesion through Downregulation of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Involving Suppression of Nuclear Factor-κB Signaling Pathway Journal article
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2015,Volume: 21,Issue: 5,Page: 361-368
Authors:  YANG Bin-rui;  YU Nan;  DENG Yan-hui;  HOI Pui Man;  YANG Bin;  LIU Guang-yu;  CONG Wei-hong;  Simon Ming-Yuen Lee
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L-tetrahydropalmatine  Atherosclerosis  Cell Adhesion Molecules  Tumor Necrosis Factor-α  Nuclear Factor-κb  
Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells Journal article
PLANT JOURNAL, 2017,Volume: 92,Issue: 3,Page: 452-468
Authors:  Hisa Hui Ling Tseng;  Chi Teng Vong;  Yiu Wa Kwan;  Simon Ming Yuen Lee;  Maggie Pui Man Hoi
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High Glucose  Lysosomal Ca2++++  Ca2++++ Homeostasis  Lysosomal Exocytosis  Interleukin-1β  Monocytes  
Myricanol rescues dexamethasone‐induced muscle dysfunction via a sirtuin 1‐dependent mechanism Journal article
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2019,Volume: 10,Issue: 2,Page: 429-444
Authors:  Shengnan Shen;  Qiwen Liao;  Jingxin Liu;  Ruile Pan;  Simon Ming-Yuen Lee;  Ligen Lin1
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Autophagy  Dexamethasone  Muscle Atrophy  Myricanol  Pgc-1α  Sirt1  
Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from Polygonum cuspidatum in PC12 Cells Journal article
PLANTA MEDICA, 2011,Volume: 77,Issue: 4,Page: 354-361
Authors:  Li, YB;  Lin, ZQ;  Zhang, ZJ;  Wang, MW;  Zhang, HA;  Zhang, Q;  Lee, SMY;  Wang, YT;  Hoi, PM
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Apoptosis  Polygonum Cuspidatum  Polygonaceae  2-methoxy-6-acetyl-7-methyljuglone  Oxidative Stress  Neuroprotection  
Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells Journal article
Free Radical Biology and Medicine, 2014,Volume: 74,Page: 283-293
Authors:  Chong, CM;  Shen, MY;  Zhou, ZY;  Pan, PC;  Hoi, PM;  Li, S;  Liang, W;  Ai, NN;  Zhang, LQ;  Li, CW;  Yu, HD;  Hou, TJ;  Lee, SMY
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Parkinson Disease  Free Radicals  No  Ros  Rock  Benzofuran  Mpp++++  
A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-kappa B and the PKC alpha/PI3-K/Akt pathways Journal article
NEUROCHEMISTRY INTERNATIONAL, 2014,Volume: 78,Page: 76-85
Authors:  Xu, Da-Ping;  Zhang, Kun;  Zhang, Zai-Jun;  Sun, Ye-Wei;  Guo, Bao-Jian;  Wang, Yu-Qiang;  Hoi, Pui-Man;  Han, Yi-Fan;  Lee, Simon Ming-Yuen
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Neuroinflammation  Tetramethylpyrazine Derivative  6-hydroxydopamine  Neuroprotection  
L-tetrahydropalamatine inhibits tumor necrosis factor-alpha-induced monocyte-endothelial cell adhesion through downregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 involving suppression of nuclear factor-kappa B signaling pathway Journal article
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2015,Volume: 21,Issue: 5,Page: 361-368
Authors:  Bin-rui Yang;  Nan Yu;  Yan-hui Deng;  Pui Man Hoi;  Bin Yang;  Guang-yu Liu;  Wei-hong Cong;  Simon Ming-Yuen Lee
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Nuclear Factor-kappa b  L-tetrahydropalmatine  Atherosclerosis  Cell Adhesion Molecules  Tumor Necrosis Factor-alpha  
Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3 β pathways Journal article
JOURNAL OF ETHNOPHARMACOLOGY, 2015,Volume: 170,Page: 8-15
Authors:  Lun Qing Zhang;  Fei Sa;  Cheong Meng Chong;  Ying Wang;  Zhong Yan Zhou;  Raymond Chuen Chung Chang;  Shun Wan Chan;  Pui Man Hoi;  Simon Ming Yuen Lee
Favorite | View/Download:4/0 | TC[WOS]:23 TC[Scopus]:0 | Submit date:2020/04/15
6-hydroxydopamine (6-ohda)  Oxidative Stress  Parkinson׳s Disease  Schisantherin a  
Effect of Resveratrol on differentiation of cardiomyoblast Journal article
ACTA PHARMACOLOGICA SINICA, 2006,Volume: 27,Issue: 329-330
Authors:  Leong CW;  Wong CH;  Lao SC;  Leong EC;  Lao IF;  Law PT;  Fung KP;  Tsang KS;  Waye MM;  Tsui SK;  Wang YT;  Lee SM
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Resveratrol  Differentiation  Cardiomyoblast  
The Presystemic Interplay between Gut Microbiota and Orally Administered Calycosin-7-O-b-D-Glucoside Journal article
DRUG METABOLISM AND DISPOSITION, 2015,Volume: 43,Issue: 10,Page: 1601-1611
Authors:  Jian-Qing Ruan;  Shang Li;  Ya-Ping Li;  Wen-Jin Wu;  Simon Ming-Yuen Lee;  Ru Yan
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No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice Journal article
NEURAL REGENERATION RESEARCH, 2016,Volume: 11,Issue: 8,Page: 1339-1346
Authors:  Cheng-you Zheng;  Bao-jian Guo;  Wei Cai;  Wei Cui;  Shing-hung Mak;  Yu-qiang Wang;  Simon Ming-yuen Lee;  Yi-fan Han;  Zai-jun Zhang
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Nerve Regeneration  Parkinson's Disease  Bis(Propyl)-cognitin  Rasagiline  Monoamine Oxidase b  Dopamine  Multitarget  Synergism  Neuroprotection  Neural Regeneration  
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu;  Haitao Li;  Yide Li;  Yuanjia Hu;  Simon Ming Yuen Lee;  Yuqiang Wang;  Yifan Han
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Parkinson’s Disease  Mef2d  Neuroprotection  Mpp++++  Gsk3β  Danshensu/tetramethylpyrazine Derivative  
Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin Journal article
CELL DEATH DISCOVERY, 2017,Volume: 3
Authors:  Shang Li;  Nana Ai;  Mingyun Shen;  Yuanye Dang;  Cheong-Meng Chong;  Peichen Pan;  Yiu Wa Kwan;  Shun Wan Chan;  George Pak Heng Leung;  Maggie Pui Man Hoi;  Tingjun Hou;  Simon Ming-Yuen Lee
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A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Guozhen Cui;  Qiqi Xin;  Hisa Hui Ling Tseng;  Maggie PuiMan Hoi;  Yan Wang;  Binrui Yang;  InLeng Choi;  Yuqiang Wang;  Rong Yuan;  Keji Chen;  Weihong Cong;  Simon MingYuen Lee
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Cardioprotection  Angiogenesis  Adtm  Zebrafish  Vegf  
Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease Journal article
DRUG DISCOVERY TODAY, 2019,Volume: 24,Issue: 1,Page: 189-197
Authors:  Qiwen Liao;  Yu Feng;  Binrui Yang;  Simon Ming-Yuen Lee
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Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat Journal article
BIOMED RESEARCH INTERNATIONAL, 2019,Volume: 2019
Authors:  Yu Feng;  Yan Chen;  Binrui Yang;  Qingping Lan;  Tao Wang;  Guozhen Cui;  Zhitao Ren;  I. Cheong Choi;  George Pak-Heng Leung;  Fenggen Yan;  Dacan Chen;  Hon Ho Yu;  Simon Ming Yuen Lee
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Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice Journal article
FOOD & FUNCTION, 2019,Volume: 10,Issue: 2,Page: 1212-1224
Authors:  Xiaoli Wu;  Benqin Tang;  Xian Liao;  Ziren Su;  Simon Ming-Yuen Lee;  Yefeng Cai;  Chuwen Li
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Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism Journal article
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2019,Volume: 10,Issue: 2,Page: 429-444
Authors:  Shen, SN;  Liao, QW;  Liu, JX;  Pan, RL;  Lee, SMY;  Lin, LG
Favorite | View/Download:227/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2020/01/16
Autophagy  Myricanol  Sirt1  Dexamethasone  Muscle Atrophy  Pgc-1 Alpha  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
Favorite | View/Download:225/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka