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Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
MOLECULAR BIOSYSTEMS, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:12/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2020/07/30
MITOCHONDRIA AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE Book chapter
出自: FUNCTIONS, DISEASE-RELATED DYSFUNCTIONS, AND THERAPEUTIC TARGETING OF NEURONAL MITOCHONDRIA:JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA, 2016, 页码: 322-338
Authors:  Hung, Clara Hiu-Ling;  Cheng, Sally Shuk-Yee;  Lee, Simon Ming-Yuen;  Chang, Raymond Chuen-Chung
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No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice Journal article
NEURAL REGENERATION RESEARCH, 2016,Volume: 11,Issue: 8,Page: 1339-1346
Authors:  Cheng-you Zheng;  Bao-jian Guo;  Wei Cai;  Wei Cui;  Shing-hung Mak;  Yu-qiang Wang;  Simon Ming-yuen Lee;  Yi-fan Han;  Zai-jun Zhang
Favorite | View/Download:248/0 | TC[WOS]:1 TC[Scopus]:0 | Submit date:2020/01/16
Nerve Regeneration  Parkinson's Disease  Bis(Propyl)-cognitin  Rasagiline  Monoamine Oxidase b  Dopamine  Multitarget  Synergism  Neuroprotection  Neural Regeneration  
Potent Protection Against MPP+ -Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NEUROMOLECULAR MEDICINE, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Shengquan Hu;  Liang Wang;  Shinghung Mak;  Zaijun Zhang;  Daping Xu;  Haitao Li;  Yide Li;  Yuanjia Hu;  Simon Ming Yuen Lee;  Yuqiang Wang;  Yifan Han
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Parkinson’s Disease  Mef2d  Neuroprotection  
中藥評質量價關鍵科學問題的基礎研究及其應用 Scientific research award
省级科研奖励等: 二等
Authors:  王一濤;  李紹平;  李銘源;  梁重恒;  王春明
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A Novel Danshensu Derivative Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer Cells Journal article
Journal of Cellular Biochemistry, 2016,Volume: 117,Issue: 1,Page: 94-105
Authors:  Liang Wang;  Xiaojing Zhang;  Judy Yuet‐Wa Chan;  Luchen Shan;  Guozhen Cui;  Qingbin Cui;  Yingfei Wang;  Jingjing Li;  Huanxian Chen;  Qingwen Zhang;  Pei Yu;  Yifan Han;  Yuqiang Wang;  Simon Ming‐Yuen Lee
Favorite | View/Download:17/0 | TC[WOS]:17 TC[Scopus]:20 | Submit date:2018/11/06
Breast Cancer  Cardiotoxicity  Doxorubicin  Mitochondrial Biogenesis  
The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides Journal article
Genome Biology and Evolution, 2016,Volume: 8,Issue: 9,Page: 3045-3064
Authors:  Chen Huang;  Jean-Étienne RL Morlighem;  Hefeng Zhou;  Érica P Lima;  Paula B Gomes;  Jing Cai;  Inchio Lou;  Carlos D Pérez;  Simon Ming Lee;  Gandhi Rádis-Baptista
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Hexacorallia  Molecular Toxinology  Peptide Toxin  Rna-seq  Transcriptome  Venomics  Zoanthidea  
FGF2 Prevents Sunitinib-Induced Cardiotoxicity in Zebrafish and Cardiomyoblast H9c2 Cells Journal article
Cardiovascular Toxicology, 2016,Volume: 16,Issue: 1,Page: 46-53
Authors:  Guozhen Cui;  Huanxian Chen;  Wei Cui;  Xiaogang Guo;  Jiansong Fang;  Ailin Liu;  Yonglong Chen;  Simon Ming Yuen Lee
Favorite | View/Download:8/0 | TC[WOS]:11 TC[Scopus]:12 | Submit date:2018/11/06
Cardiotoxicity  Fgf2  Plc-γ/c-raf/creb  Sunitinib  Zebrafish  
Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine Journal article
European Journal of Pharmacology, 2016,Volume: 791,Page: 544-551
Authors:  Tang P.C.T.;  Yang C.;  Li R.W.-S.;  Lee S.M.-Y.;  Hoi M.P.-M.;  Chan S.-W.;  Kwan Y.-W.;  Tse C.-M.;  Leung G.P.-H.
Favorite | View/Download:18/0 | TC[WOS]:4 TC[Scopus]:7 | Submit date:2018/11/06
Cancer  Cardiovascular Disease  Equilibrative Nucleoside Transporters  Inhibitor  
Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs Journal article
European Journal of Pharmacology, 2016,Volume: 789,Page: 344-353
Authors:  JingjingLia;  YuranPeng;  Shang Li;  Yicheng Sun;  Judy Yuet-Wa Chan;  Guozhen Cui;  Decai Wang;  Guo-Chun Zhou;  Simon Ming-Yuen Lee
Favorite | View/Download:10/0 | TC[WOS]:12 TC[Scopus]:13 | Submit date:2018/11/06
Andrographolide  Angiogenesis  Zebrafish  
Differential: In vitro and in vivo anti-angiogenic activities of acetal and ketal andrographolide derivatives in HUVEC and zebrafish models Journal article
RSC Advances, 2016,Volume: 6,Issue: 105,Page: 102831-102842
Authors:  Dekuan Sheng;  Jingjing Li;  Kun Wang;  Yuran Peng;  Shang Li;  Yicheng Sun;  Zhuyun Liu;  Decai Wang;  Simon Ming Yuen Lee;  Guo-Chun Zhou
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Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca2+-Activated K+ Channels (BKCa) Journal article
Evidence-based Complementary and Alternative Medicine, 2016,Volume: 2016
Authors:  Tseng H.H.L.;  Vong C.T.;  Leung G.P.-H.;  Seto S.W.;  Kwan Y.W.;  Lee S.M.-Y.;  Hoi M.P.M.
Favorite | View/Download:9/0 | TC[WOS]:2 TC[Scopus]:5 | Submit date:2018/11/06
Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2T from Lop Nor region, China Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Huang C.;  Leung R.K.-K.;  Guo M.;  Tuo L.;  Guo L.;  Yew W.W.;  Lou I.;  Lee S.M.Y.;  Sun C.
Favorite | View/Download:18/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/11/06
Antrodia camphorata increases insulin secretion and protects from apoptosis in MIN6 cells Journal article
Frontiers in Pharmacology, 2016,Volume: 7,Issue: MAR
Authors:  Chi Teng Vong;  Hisa Hui Ling Tseng;  Yiu Wa Kwan;  Simon Ming-Yuen Lee;  Maggie Pui Man Hoi
Favorite | View/Download:9/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/11/06
Antrodia Camphorata  Insulin Secretion  Pancreatic Β-cell Death  Ppar-γ  Type 2 Diabetes Mellitus  
Transport Mechanism of Coumarin 6 Nanocrystals with Two Particle Sizes in MDCKII Monolayer and Larval Zebrafish Journal article
ACS Applied Materials and Interfaces, 2016,Volume: 8,Issue: 20,Page: 12620-12630
Authors:  Xiaoqing Miao;  Ye Li;  Xueqing Wang;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:10/0 | TC[WOS]:24 TC[Scopus]:28 | Submit date:2018/11/06
Epithelial Cells  Nanocrystals  Particle Size  Transport Mechanism  Zebrafish  
A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II Journal article
Oncotarget, 2016,Volume: 7,Issue: 22,Page: 32054-32064
Authors:  Wang L.;  Zhang X.;  Cui G.;  Chan J.Y.-W.;  Wang L.;  Li L.;  Shan L.;  Xu C.;  Zhang Q.;  Wang Y.;  Di L.;  Lee S.M.-Y.
Favorite | View/Download:15/0 | TC[WOS]:20 TC[Scopus]:27 | Submit date:2018/11/06
Breast Cancer  Danshensu  Mitochondrial Complex Ii  Reactive Oxygen Species  Tetramethylpyrazine  
Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B Journal article
Journal of Agricultural and Food Chemistry, 2016,Volume: 64,Issue: 26,Page: 5324-5333
Authors:  Baojian Guo;  Chengyou Zheng;  Wei Cai;  Jiehong Cheng;  Hongyu Wang;  Haitao Li;  Yewei Sun;  Wei Cui;  Yuqiang Wang;  Yifan Han;  Simon Ming-Yuen Lee;  Zaijun Zhang
Favorite | View/Download:24/0 | TC[WOS]:11 TC[Scopus]:20 | Submit date:2018/11/06
Chrysin  Mao-b  Mef2d  Neuroprotection  Parkinson's Disease  
Discovery, synthesis, and functional characterization of a novel neuroprotective natural product from the fruit of alpinia oxyphylla for use in Parkinson's disease through LC/MS-based multivariate data analysis-guided fractionation Journal article
Journal of Proteome Research, 2016,Volume: 15,Issue: 8,Page: 2595-2606
Authors:  Guohui Li;  Zaijun Zhang;  Quan Quan;  Renwang Jiang;  Samuel S.W. Szeto;  Shuai Yuan;  Wing-tak Wong;  Herman H. C. Lam;  Simon Ming-Yuen Lee;  Ivan K. Chu
Favorite | View/Download:14/0 | TC[WOS]:16 TC[Scopus]:17 | Submit date:2018/11/06
Natural Products  Neuroprotective  Nrf2  Parkinson's Disease  Proteomics  
A novel agent enhances the chemotherapeutic efficacy of doxorubicin in MCF-7 breast cancer cells Journal article
Frontiers in Pharmacology, 2016,Volume: 7,Issue: AUG
Authors:  Wang L.;  Chan J.Y.;  Zhou X.;  Cui G.;  Yan Z.;  Wang L.;  Yan R.;  Di L.;  Wang Y.;  Hoi M.P.;  Shan L.;  Lee S.M.
Favorite | View/Download:16/0 | TC[WOS]:8 TC[Scopus]:10 | Submit date:2018/11/06
Breast Cancer  Danshensu  Doxorubicin  Glycolysis  Grp78 Protein  Tetramethylpyrazine  
Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening Journal article
Molecular BioSystems, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:15/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/11/06