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PRAJA is overexpressed in glioblastoma and contributes to neural precursor development Journal article
Genes and Cancer, 2017,Volume: 8,Issue: 7-8,Page: 640-649
Authors:  Shin,Joshua;  Mishra,Viveka;  Glasgow,Eric;  Zaidi,Sobia;  Ohshiro,Kazufumi;  Chitti,Bhargava;  Chen,Jian;  Kapadia,Amee A.;  Rana,Neha;  Mishra,Lopa;  Deng,Chu Xia;  Rao,Shuyun;  Mishra,Bibhuti
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Apoptosis  Glioblastoma  PRAJA  
Fibroblast growth factor receptor 2 signaling in breast cancer Journal article
International Journal of Biological Sciences, 2017,Volume: 13,Issue: 9,Page: 1163-1171
Authors:  Lei,Haipeng;  Deng,Chu Xia
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Breast cancer  FGFR2  Inhibitor  Mutation  Polymorphism  
Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice Journal article
Journal of Cellular Physiology, 2018,Volume: 234,Issue: 1,Page: 595-605
Authors:  Wang,Quan;  Tan,Qiaoyan;  Xu,Wei;  Kuang,Liang;  Zhang,Bin;  Wang,Zuqiang;  Ni,Zhenhong;  Su,Nan;  Jin,Min;  Li,Can;  Jiang,Wanling;  Huang,Junlan;  Li,Fangfang;  Zhu,Ying;  Chen,Hangang;  Du,Xiaolan;  Chen,Di;  Deng,Chuxia;  Qi,Huabing;  Xie,Yangli;  Chen,Lin
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activing receptor-like kinases 5 (ALK5)  matrix degradation  meniscal degeneration  transforming growth factor-β (TGF-β) signaling  
Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway Journal article
Gastroenterology, 2018,Volume: 154,Issue: 1,Page: 195-210
Authors:  Chen,Jian;  Zaidi,Sobia;  Rao,Shuyun;  Chen,Jiun Sheng;  Phan,Liem;  Farci,Patrizia;  Su,Xiaoping;  Shetty,Kirti;  White,Jon;  Zamboni,Fausto;  Wu,Xifeng;  Rashid,Asif;  Pattabiraman,Nagarajan;  Mazumder,Raja;  Horvath,Anelia;  Wu,Ray Chang;  Li,Shulin;  Xiao,Cuiying;  Deng,Chu Xia;  Wheeler,David A.;  Mishra,Bibhuti;  Akbani,Rehan;  Mishra,Lopa
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COSMIC  Gene Regulation  Genetics  Immune Response  Liver Cancer  
Effect of stromal cells in tumor microenvironment on metastasis initiation Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 14,Page: 2083-2093
Authors:  Guo,Sen;  Deng,Chu Xia
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Breast cancer  Metastasis initiation  Stromal cells  TME  
The role of TGF-β/SMAD4 signaling in cancer Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 2,Page: 111-123
Authors:  Zhao,Ming;  Mishra,Lopa;  Deng,Chu Xia
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Mouse model  Prognosis  SMAD4  TGF-β  Tumorigenesis  
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis Journal article
Oncogene, 2018,Volume: 37,Issue: 17,Page: 2343-2350
Authors:  Lahusen,Tyler J.;  Kim,Seung Jin;  Miao,Kai;  Huang,Zebin;  Xu,Xiaoling;  Deng,Chu Xia
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Generation of Smurf2 conditional knockout mice Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 542-548
Authors:  Tang,Yi;  Tang,Liu Ya;  Xu,Xuan;  Li,Cuiling;  Deng,Chuxia;  Zhang,Ying E.
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Knockout  Liver  LoxP  Mice  Smurf2  
Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia Journal article
Journal of Biological Chemistry, 2018,Volume: 293,Issue: 22
Authors:  Sun,Heng;  Miao,Zhengqiang;  Zhang,Xin;  Chan,Un In;  Su,Sek Man;  Guo,Sen;  Wong,Chris Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
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A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 10,Page: 1389-1398
Authors:  Tan,Qiaoyan;  Wang,Zuqiang;  Wang,Quan;  Wang,Yuanqiang;  Huang,Zhifeng;  Su,Nan;  Jin,Min;  Kuang,Liang;  Qi,Huabing;  Ni,Zhenhong;  Li,Can;  Zhu,Ying;  Jiang,Wanling;  Chen,Hangang;  Deng,Chuxia;  Du,Xiao Lan;  Xie,Yang Li;  Chen,Lin
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Cancer therapy  FGFR1  Lung cancer  Peptide  Phage display  
Conditional deletion of FOXL2 and SMAD4 in gonadotropes of adult mice causes isolated FSH deficiency Journal article
Endocrinology, 2018,Volume: 159,Issue: 7,Page: 2641-2655
Authors:  Li,Yining;  Schang,Gauthier;  Wang,Ying;  Zhou,Xiang;  Levasseur,Adrien;  Boyer,Alexandre;  Deng,Chu Xia;  Treier,Mathias;  Boehm,Ulrich;  Boerboom,Derek;  Bernard,Daniel J.
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Inhibition of estrogen signaling reduces the incidence of BRCA1-associated mammary tumor formation Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 12,Page: 1755-1768
Authors:  Baek,Hye Jung;  Kim,Sun Eui;  Choi,Eun Kyung;  Kim,Jong Kwang;  Shin,Dong Hoon;  Park,Eun Jung;  Kim,Tae Hyun;  Kim,Joo Young;  Kim,Kwang Gi;  Deng,Chu Xia;  Kim,Sang Soo
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BRCA1  Cancer prevention  Estrogen  Fulvestrant  
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors Journal article
Experimental and Molecular Medicine, 2018,Volume: 50,Issue: 10
Authors:  Choi,Eun Kyung;  Lim,Jeong A.;  Kim,Jong Kwang;  Jang,Moon Sun;  Kim,Sun Eui;  Baek,Hye Jung;  Park,Eun Jung;  Kim,Tae Hyun;  Deng,Chu Xia;  Wang,Rui Hong;  Kim,Sang Soo
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Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 13,Page: 1769-1781
Authors:  Baek,Hye Jung;  Kim,Sun Eui;  Kim,Jong Kwang;  Shin,Dong Hoon;  Kim,Tae Hyun;  Kim,Kwang Gi;  Deng,Chu Xia;  Kim,Sang Soo
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AKT  BRCA1  MK-2206  Precision medicine  
Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model Journal article
Molecular Therapy - Nucleic Acids, 2018,Volume: 13,Page: 291-302
Authors:  Luo,Fengtao;  Xie,Yangli;  Wang,Zuqiang;  Huang,Junlan;  Tan,Qiaoyan;  Sun,Xianding;  Li,Fangfang;  Li,Can;  Liu,Mi;  Zhang,Dali;  Xu,Meng;  Su,Nan;  Ni,Zhenhong;  Jiang,Wanling;  Chang,Jinhong;  Chen,Hangang;  Chen,Shuai;  Xu,Xiaoling;  Deng,Chuxia;  Wang,Zhugang;  Du,Xiaolan;  Chen,Lin
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adeno-associated virus  Apert syndrome  craniosynostosis  Fgfr2  molecular therapy  RNAi  
SMAD signaling promotes melanoma metastasis independently of phenotype switching Journal article
Journal of Clinical Investigation, 2019,Volume: 129,Issue: 7,Page: 2702-2716
Authors:  Tuncer,Eylul;  Calçada,Raquel R.;  Zingg,Daniel;  Varum,Sandra;  Cheng,Phil;  Freiberger,Sandra N.;  Deng,Chu Xia;  Kleiter,Ingo;  Levesque,Mitchell P.;  Dummer,Reinhard;  Sommer,Lukas
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Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy Journal article
Chemical Communications, 2019,Volume: 55,Issue: 95,Page: 14255-14258
Authors:  Zhu,Lipeng;  Liu,Jie;  Zhou,Guangyu;  Ng,Hoi Man;  Ang,Irene L.;  Ma,Guofang;  Liu,Yubin;  Yang,Shuo;  Zhang,Fengjuan;  Miao,Kai;  Poon,Terence C.W.;  Zhang,Xuanjun;  Yuan,Zhen;  Deng,Chu Xia;  Zhao,Qi
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SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions Journal article
Autophagy, 2019,Volume: 15,Issue: 8,Page: 1356-1375
Authors:  Kim,Tae Sung;  Jin,Yeung Bae;  Kim,Yi Sak;  Kim,Sup;  Kim,Jin Kyung;  Lee,Hye Mi;  Suh,Hyun Woo;  Choe,Jin Ho;  Kim,Young Jae;  Koo,Bon Sang;  Kim,Han Na;  Jung,Mingyu;  Lee,Sang Hee;  Kim,Don Kyu;  Chung,Chaeuk;  Son,Ji Woong;  Min,Jung Joon;  Kim,Jin Man;  Deng,Chu Xia;  Kim,Hyun Seok;  Lee,Sang Rae;  Jo,Eun Kyeong
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autophagy  mitochondrial homeostasis  Mycobacterium tuberculosis  PPARA  SIRT3  
Optimizing CRISPR/Cas9 technology for precise correction of the Fgfr3-G374R mutation in achondroplasia in mice Journal article
Journal of Biological Chemistry, 2019,Volume: 294,Issue: 4,Page: 1142-1151
Authors:  Miao,Kai;  Zhang,Xin;  Su,Sek Man;  Zeng,Jianming;  Huang,Zebin;  Chan,Un In;  Xu,Xiaoling;  Deng,Chu Xia
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Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism Journal article
Cell Metabolism, 2019,Volume: 30,Issue: 2,Page: 385-401.e9
Authors:  Collin de l'Hortet,Alexandra;  Takeishi,Kazuki;  Guzman-Lepe,J.;  Morita,Kazutoyo;  Achreja,Abhinav;  Popovic,Branimir;  Wang,Yang;  Handa,Kan;  Mittal,Anjali;  Meurs,Noah;  Zhu,Z.;  Weinberg,F.;  Salomon,Michael;  Fox,I. J.;  Deng,Chu Xia;  Nagrath,Deepak;  Soto-Gutierrez,Alejandro
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cellular engineering  hepatic differentiation  human fatty liver  human iPSCs  liver metabolism  NAFLD  NASH  SIRT1