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Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
Wang, Yuxi1; Chew, Qian Hui2; Lin, Shih Ku3,4; Yang, Shu Yu5; Ouyang, Wen Chen6,7,8; Chen, Chih Ken9; Park, Seon Cheol10,11; Jang, Ok Jin12; Park, Jun Hyuk13; Chee, Kok Yoon14; Ding, Kwong Sen15; Chong, Jamaline16; Zhang, Ling17; Li, Keqing18; Zhu, Xiaomin19; Jatchavala, Chonnakarn20; Pariwatcharakul, Pornjira21; Kallivayalil, Roy Abraham22; Grover, Sandeep23; Avasthi, Ajit23; Ansari, Moin24; Maramis, Margarita M.25; Aung, Paing Phyo26; Sartorius, Norman27; Xiang, Yu Tao28,29,30; Tan, Chay Hoon31; Chong, Mian Yoon32; Park, Yong Chon33; Kato, Takahiro A.34; Shinfuku, Naotaka35; Baldessarini, Ross J.36,37; Sim, Kang1,2
Source PublicationJournal of Clinical Psychopharmacology

Background Because use and dosing of mood stabilizers (MSs) to treat bipolar disorder (BD) patients in Asia are not well documented, we examined prevalence and clinical correlates of treatment of Asian BD patients with relatively high doses of MSs. Methods We conducted a pharmacoepidemiological survey across 13 Asian countries and territory in the Research on Asian Psychotropic Prescription Patterns Consortium. Mood stabilizer doses were converted to lithium carbonate equivalents (Li-eq milligrams per day). We compared relatively high (>900 Li-eq mg/day) versus lower MS doses by bivariate comparisons, followed by multivariable linear regression to identify factors associated with higher MS doses. Results Among 1647 participants, MS dose averaged 584 (confidence interval, 565-603 Li-eq mg/d). Preliminarily, the 13.1% of the subjects given greater than 900 mg/d versus those given lower doses were younger, male, currently hospitalized, not currently depressed, and reported lifetime suicidal ideation; they also received relatively high doses of antipsychotics, received electroconvulsive treatment within the previous 12 months, and had greater ratings of tremors and sedation. By linear regression modeling, the mean proportion given high doses of MS was associated significantly and independently with higher doses of antipsychotics, younger age, male sex, hospitalized, more years of illness, country, higher body mass index, recent electroconvulsive treatment, and being in illness remission. Conclusions Relatively high doses of MSs for BD are prevalent, but vary markedly among Asian countries, and are particularly likely among young males, ill for many years, and given high doses of antipsychotics or ECT. These characteristics allow better identification of patient profiles that can guide treatment of BD patients.

KeywordAsia Bipolar Disorder Doses Mood Stabilizers
URLView the original
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy ; Psychiatry
WOS SubjectPharmacology & Pharmacy;psychiatry
WOS IDWOS:000787870700010
Scopus ID2-s2.0-85129373833
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSim, Kang
Affiliation1.Institute of Mental Health/ Woodbridge Hospital 10, Buangkok View, 539747, Singapore
2.Research Division, Institute of Mental Health, Singapore
3.Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
4.Department of Psychiatry, Taipei City Hospital and Psychiatric Center, Taiwan
5.Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan
6.Department of Geriatric Psychiatry, Jianan Psychiatric Center, Tainan, Taiwan
7.Department of Psychiatry, Kaohsiung Medical University, Taiwan
8.Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan
9.Chang Gung Memorial Hospital, Keelung Branch, Keelung, Taiwan
10.Department of Psychiatry, Hanyang University College of Medicine, Seoul, South Korea
11.Department of Psychiatry, Hanyang University Guri Hospital, Guri, South Korea
12.Department of Psychiatry, Bugok National Hospital, Changnyong, South Korea
13.Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea
14.Department of Psychiatry and Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
15.Department of Psychiatry, Hospital Bahagia Ulu Kinta, Tanjung Rambutan, Perak Darul Ridzwan, Malaysia
16.Hospital Permai Johor Bahru, Ministry of Health, Johor Bahru, Malaysia
17.National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, School of Mental Health, Beijing, China
18.Hebei Provincical Mental Health Center Baoding, Hebei, China
19.Department of Psychiatry, Suzhou Guangji Hospital, Affiliated Guangji Hospital of Soochow University, Suzhou, China
20.Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
21.Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
22.Department of Psychiatry, Pushpagiri Institute of Medical Sciences, Tiruvalla, India
23.Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India
24.Department of Psychiatry, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
25.Department of Psychiatry, Dr Soetomo Hospital-Faculty of Medicine, Airlangga University, Surabaya, Indonesia
26.Mental Health Hospital, Yangon University of Medicine, Yangon, Myanmar
27.Association for the Improvement of Mental Health Programs, Geneva, Switzerland
28.Unit of Psychiatry, Department of Public Health and Medicinal Administration, and Institute of Translational Medicine, Faculty of Health Sciences, India
29.Centre for Cognitive and Brain Sciences, University of Macau, Macao
30.Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao SAR, Macao
31.Department of Pharmacology, National University of Singapore, Singapore
32.Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and School of Medicine, Chang Gung University, Taoyuan, Taiwan
33.Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, South Korea
34.Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Japan
35.School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan
36.International Consortium for Mood and Psychotic Disorder Research, McLean Hospital, Belmont, United States
37.Department of Psychiatry, Harvard Medical School, Boston, United States
Recommended Citation
GB/T 7714
Wang, Yuxi,Chew, Qian Hui,Lin, Shih Ku,et al. Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study[J]. Journal of Clinical Psychopharmacology,2022,42(3):293-297.
APA Wang, Yuxi.,Chew, Qian Hui.,Lin, Shih Ku.,Yang, Shu Yu.,Ouyang, Wen Chen.,Chen, Chih Ken.,Park, Seon Cheol.,Jang, Ok Jin.,Park, Jun Hyuk.,Chee, Kok Yoon.,Ding, Kwong Sen.,Chong, Jamaline.,Zhang, Ling.,Li, Keqing.,Zhu, Xiaomin.,Jatchavala, Chonnakarn.,Pariwatcharakul, Pornjira.,Kallivayalil, Roy Abraham.,Grover, Sandeep.,...&Sim, Kang.(2022).Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study.Journal of Clinical Psychopharmacology,42(3),293-297.
MLA Wang, Yuxi,et al."Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study".Journal of Clinical Psychopharmacology 42.3(2022):293-297.
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