UM  > Institute of Chinese Medical Sciences
Residential Collegefalse
Status已發表Published
Extracts from Radix Astragali and Radix Rehmanniae promote keratinocyte proliferation by regulating expression of growth factor receptors
Ren J.W.; Chan K.M.; Lai P.K.K.; Lau C.B.S.; Yu H.; Leung P.C.; Fung K.P.; Yu W.F.X.; Cho C.H.
2012-10-01
Source PublicationPhytotherapy Research
ISSN0951418X 10991573
Volume26Issue:10Pages:1547-1554
Abstract

Chinese herbal medicine has long been used as a treatment for wounds. However, the underlying cellular and molecular mechanisms remain largely unknown. In this study it was shown that the proliferation of keratinocytes, which is known to play an important role in wound healing as the major cell type in the epidermis, was promoted by three herbal extracts/natural compounds: NF3 (an extract from the mixture of Radix Astragali (RA) and Radix Rehmanniae (RR) in the ratio of 2:1), stachyose (an isolated compound from Radix Rehmanniae) and extract P2-2 (a sub-fraction from the extract of Radix Astragali). The effect of the herbal extracts/natural compounds on the growth of keratinocytes was not influenced by a high glucose level, a condition similar to diabetic patients who usually suffer from diabetic foot ulcers. Real time RT-PCR results showed that the expression of epidermal growth factor (EGF) receptor, but not transforming growth factor-β (TGF-β) receptor, was up-regulated by NF3. Moreover, treatments with the EGF receptor kinase inhibitor AG1478 and the MEK inhibitor U0126 resulted in the diminishment of the effect of the three herbal extracts/natural compounds on keratinocyte proliferation, indicating that EGF receptor might have a significant role in this action. This study has further elucidated the molecular mechanism under which herbal extracts/natural compounds exert their effects on the wound healing process. Copyright © 2012 John Wiley & Sons, Ltd.

Keywordg Protein-coupled Receptors Keratinocyte Proliferation Nf3 P2-2 Stachyose
DOI10.1002/ptr.4615
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000309592900018
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationChinese University of Hong Kong
Recommended Citation
GB/T 7714
Ren J.W.,Chan K.M.,Lai P.K.K.,et al. Extracts from Radix Astragali and Radix Rehmanniae promote keratinocyte proliferation by regulating expression of growth factor receptors[J]. Phytotherapy Research,2012,26(10):1547-1554.
APA Ren J.W.,Chan K.M.,Lai P.K.K.,Lau C.B.S.,Yu H.,Leung P.C.,Fung K.P.,Yu W.F.X.,&Cho C.H..(2012).Extracts from Radix Astragali and Radix Rehmanniae promote keratinocyte proliferation by regulating expression of growth factor receptors.Phytotherapy Research,26(10),1547-1554.
MLA Ren J.W.,et al."Extracts from Radix Astragali and Radix Rehmanniae promote keratinocyte proliferation by regulating expression of growth factor receptors".Phytotherapy Research 26.10(2012):1547-1554.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ren J.W.]'s Articles
[Chan K.M.]'s Articles
[Lai P.K.K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ren J.W.]'s Articles
[Chan K.M.]'s Articles
[Lai P.K.K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ren J.W.]'s Articles
[Chan K.M.]'s Articles
[Lai P.K.K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.