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SARS-CoV-2 and the Nucleus
Chen, Mengqi; Ma, Yue; Chang, Wakam
2022-07
Source PublicationInternational Journal of Biological Sciences
ISSN1449-2288
Volume18Issue:12Pages:4731-4743
Abstract

The ongoing COVID-19 pandemic is caused by an RNA virus, SARS-CoV-2. The genome of SARS-CoV-2 lacks a nuclear phase in its life cycle and is replicated in the cytoplasm. However, interfering with nuclear trafficking using pharmacological inhibitors greatly reduces virus infection and virus replication of other coronaviruses is blocked in enucleated cells, suggesting a critical role of the nucleus in virus infection. Here, we summarize the alternations of nuclear pathways caused by SARS-CoV-2, including nuclear translocation pathways, innate immune responses, mRNA metabolism, epigenetic mechanisms, DNA damage response, cytoskeleton regulation, and nuclear rupture. We consider how these alternations contribute to virus replication and discuss therapeutic treatments that target these pathways, focusing on small molecule drugs that are being used in clinical studies.

KeywordSars-cov-2 Nuclear Transport Innate Immunity Epigenetics Cilia Dna Damage
DOI10.7150/ijbs.72482
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000828439300022
Scopus ID2-s2.0-85134232151
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChang, Wakam
AffiliationDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
Recommended Citation
GB/T 7714
Chen, Mengqi,Ma, Yue,Chang, Wakam. SARS-CoV-2 and the Nucleus[J]. International Journal of Biological Sciences,2022,18(12):4731-4743.
APA Chen, Mengqi,Ma, Yue,&Chang, Wakam.(2022).SARS-CoV-2 and the Nucleus.International Journal of Biological Sciences,18(12),4731-4743.
MLA Chen, Mengqi,et al."SARS-CoV-2 and the Nucleus".International Journal of Biological Sciences 18.12(2022):4731-4743.
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