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The drug likeness analysis of anti‑inflammatory clerodane diterpenoids
Feng, Z.; Cao, J.; Zhang, Q. W.; Lin, L.
2020-12-09
Source PublicationChinese Medicine
ISSN2151-1918
Pages126-126
Abstract

Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it’s urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.

KeywordClerodane Diterpenoids Anti-inflammation Drug-likeness Swissadme
Language英語English
The Source to ArticlePB_Publication
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLin, L.
Recommended Citation
GB/T 7714
Feng, Z.,Cao, J.,Zhang, Q. W.,et al. The drug likeness analysis of anti‑inflammatory clerodane diterpenoids[J]. Chinese Medicine,2020:126-126.
APA Feng, Z.,Cao, J.,Zhang, Q. W.,&Lin, L..(2020).The drug likeness analysis of anti‑inflammatory clerodane diterpenoids.Chinese Medicine,126-126.
MLA Feng, Z.,et al."The drug likeness analysis of anti‑inflammatory clerodane diterpenoids".Chinese Medicine (2020):126-126.
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