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Neuroendocrine-Immune Regulatory Network of Eucommia ulmoides Oliver
Zhao, Yi1; Tan, De-Chao1; Peng, Bo1; Yang, Lin1; Zhang, Si-Yuan1; Shi, Rui-Peng1; Chong, Cheong-Meng1; Zhong, Zhang-Feng1; Wang, Sheng-Peng1; Liang, Qiong-Lin2; Wang, Yi-Tao1
2022-06
Source PublicationMolecules
Volume27Issue:12Pages:3697
Abstract

Eucommia ulmoides Oliver (E. ulmoides) is a popular medicinal herb and health supplement in China, Japan, and Korea, and has a variety of pharmaceutical properties. The neuroendocrine-immune (NEI) network is crucial in maintaining homeostasis and physical or psychological functions at a holistic level, consistent with the regulatory theory of natural medicine. This review aims to systematically summarize the chemical compositions, biological roles, and pharmacological properties of E. ulmoides to build a bridge between it and NEI-associated diseases and to provide a perspective for the development of its new clinical applications. After a review of the literature, we found that E. ulmoides has effects on NEI-related diseases including cancer, neurodegenerative disease, hyperlipidemia, osteoporosis, insomnia, hypertension, diabetes mellitus, and obesity. However, clinical studies on E. ulmoides were scarce. In addition, E. ulmoides derivatives are diverse in China, and they are mainly used to enhance immunity, improve hepatic damage, strengthen bones, and lower blood pressure. Through network pharmacological analysis, we uncovered the possibility that E. ulmoides is involved in functional interactions with cancer development, insulin resistance, NAFLD, and various inflammatory pathways associated with NEI diseases. Overall, this review suggests that E. ulmoides has a wide range of applications for NEI-related diseases and provides a direction for its future research and development.

Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000816349800001
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChong, Cheong-Meng
Affiliation1.Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
2.MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Department of Chemistry, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhao, Yi,Tan, De-Chao,Peng, Bo,et al. Neuroendocrine-Immune Regulatory Network of Eucommia ulmoides Oliver[J]. Molecules,2022,27(12):3697.
APA Zhao, Yi,Tan, De-Chao,Peng, Bo,Yang, Lin,Zhang, Si-Yuan,Shi, Rui-Peng,Chong, Cheong-Meng,Zhong, Zhang-Feng,Wang, Sheng-Peng,Liang, Qiong-Lin,&Wang, Yi-Tao.(2022).Neuroendocrine-Immune Regulatory Network of Eucommia ulmoides Oliver.Molecules,27(12),3697.
MLA Zhao, Yi,et al."Neuroendocrine-Immune Regulatory Network of Eucommia ulmoides Oliver".Molecules 27.12(2022):3697.
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