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Phytochemistry and Pharmacology, Quality control of Xiasangju: A Traditional Chinese Medicine Formula
Siyuan Wu1; Hua Luo1; Zhangfeng Zhong1; Yongjian Ai2; Yonghua Zhao1; Qionglin Liang2; Yitao Wang1
2022-06
Source PublicationFrontiers in Pharmacology
Volume13Pages:930813
Abstract

As a traditional Chinese herbal formula, Xiasangju (XSJ) is widely used in China for antipyresis and influenza treatment. However, XSJ still fails to have a comprehensive summary of the research progress in the last decade. This review summarizes the advanced research on the extraction process, phytochemistry, pharmacological activity, and quality control of XSJ. Current research mainly focuses on quality control and the pharmacological effects of single herbs and active ingredients, but many pharmacological mechanisms of the formula are unclear. The development of active ingredients reflects the active characteristics of triterpenes, phenolic acids and flavonoids, but the hepatotoxicity of Prunella vulgaris L. has not been taken into account. XSJ has extensive historical practical experiences, while systematic clinical trials remain lacking. Therefore, it is necessary to study the active ingredients and define the mechanisms of XSJ to develop multiple applications, and further studies on the dose range between its hepatoprotective activity and hepatotoxicity are necessary to improve the safety of the clinical application. In this review, the current problems are discussed to facilitate the reference basis for the subsequent research on the development of XSJ and future application directions.

KeywordChrysanthemum Indicum L. Morus AL.a L. PruneL.a VuL.aris L. Xiasangju Pharmacology Phytochemistry Quality Control
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS IDWOS:000821319800001
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYonghua Zhao; Qionglin Liang; Yitao Wang
Affiliation1.University of Macau
2.Tsinghua University
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Siyuan Wu,Hua Luo,Zhangfeng Zhong,et al. Phytochemistry and Pharmacology, Quality control of Xiasangju: A Traditional Chinese Medicine Formula[J]. Frontiers in Pharmacology,2022,13:930813.
APA Siyuan Wu,Hua Luo,Zhangfeng Zhong,Yongjian Ai,Yonghua Zhao,Qionglin Liang,&Yitao Wang.(2022).Phytochemistry and Pharmacology, Quality control of Xiasangju: A Traditional Chinese Medicine Formula.Frontiers in Pharmacology,13,930813.
MLA Siyuan Wu,et al."Phytochemistry and Pharmacology, Quality control of Xiasangju: A Traditional Chinese Medicine Formula".Frontiers in Pharmacology 13(2022):930813.
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