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Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin
Ruting ZHONG1; Mohamed A. Farag2; Meiwan Che1; Chengwei He1; Jianbo Xiao3
2022-06
Source PublicationeFood
ISSN2666-3066
Volume3Issue:e3
Abstract

Fisetin is one of the most popular flavonoids found in vegetables and fruits with several health benefits such as antidiabetic, anticancer, and anti-inflammatory activities. Biotechnology or chemosynthesis tools were used for the synthesis of fisetin and its analogs to improve their yield and efficacy. Structure activity relationships (SARs) revealed that the aromatic hydroxyl groups especially the 3,4-dihydroxylation at ring B were crucial for fisetin biological activities, whereas substitution of several hydroxyl groups in fisetin appeared to impact its original effects. The ongoing or upcoming clinical trials containing fisetin are applied in drugs and dietary supplements. Noteworthily, fisetin has been successfully incorporated into nutraceuticals in the market. Furthermore, the delivery system of fisetin-loaded nanocochleates showed the best bioavailability compared to other formulations. This review presents the latest research progress of fisetin on its synthesis, structure–activity relationships, pharmacokinetics, biological activities, and underlying mechanisms, bioavailability, delivery systems, and clinical trials to provide a comprehensive insight into the research and application of this valuable natural compound.

KeywordBioactivities Fisetin Molecular Mechanism Pharmacokinetics Structure–activity Relationship
DOI10.1002/efd2.3
URLView the original
Indexed By其他
Language英語English
Funding ProjectStudies on the chemical components and mechanisms for the anti-rheumatoid arthritic activity of Glycine tabacina extract
PublisherWiley Online Library
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Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRuting ZHONG; Mohamed A. Farag; Meiwan Che; Jianbo Xiao
Affiliation1.University of Macau
2.Cairo University
3.Universidade de Vigo
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Ruting ZHONG,Mohamed A. Farag,Meiwan Che,et al. Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin[J]. eFood,2022,3(e3).
APA Ruting ZHONG,Mohamed A. Farag,Meiwan Che,Chengwei He,&Jianbo Xiao.(2022).Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin.eFood,3(e3).
MLA Ruting ZHONG,et al."Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin".eFood 3.e3(2022).
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