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Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer
Hong, Fengqiu1; Geng, Xiaorui2; Min, Guangzong3; Sun, Xiang1; Zhang, Bei1,4; Yao, Youliang1; Li, Ronghui5; Wang, Jing6; Zhao, Hengyu6; Guo, Peng7; Yuan, Zhen2; Wen, Xiaofei8,9; Nie, Liming10; Liu, Gang1; Chen, Xiaoyuan11,12,13; Zhao, Qingliang1,4
2022-12-01
Source PublicationChemical Engineering Journal
ISSN1385-8947
Volume449
Abstract

Surgical resection (SR) is the major method for treating invasive or recurrent noninvasive bladder cancer (BC). However, SR still causes additional risks of urinary tract infection, bleeding and some complications that may be life-threatening. Therefore, it is of urgent medical need for new diagnosis and therapy scheme for BC. Herein, we proposed a strategy that combines dual-modality three-dimensional (3D) NIR-II photoacoustic (PA) and optical coherence tomography angiography (OCTA) molecular imaging to guide visually interventional photothermal therapy (PTT) for BC. Additionally, we developed an excellent NIR-II hyaluronic acid-IR-1048 with liposome-coated (HAPO-1048) photothermal agent for PTT of CD44 overexpressing orthotopic BC, which showed strong NIR-II optical absorption, preferable tumor targeting, excellent biocompatibility and high PTT efficacy. Combined with the NIR-II PA/PTT response of the HAPO-1048, we can achieve high sensitivity and specificity (about 2 mm diameter) dynamic monitoring and investigate the precision therapy of PTT in deep orthotopic BC (4.38 mm). Simultaneously, we can map the dynamic changes of 3D PA signals and HAPO-1048 nanoparticles (HAPO-1048 NPs) enrichment, which is closely related to the PTT efficacy. Significantly, the whole changes of complex microvascular morphometrics and angiogenesis of BC were well surveilled and assessed in vivo using OCTA. Lastly, minimally invasive interventional PTT strategy was successfully implemented to achieve a controllable and precise therapy for orthotopic BC based on laparoscopy and US guidance. In conclusion, we present a multimodal NIR-II optical imaging synergy laparoscopy interventional oncologic scheme, which should expand the current PTT technology, leading to a significant ongoing in treatment of primary tumors of urinary system.

KeywordLaparoscopy And Us Imaging Minimally Invasive Interventional Ptt Nir-ii Pa/octa
DOI10.1016/j.cej.2022.137846
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaEngineering
WOS SubjectEngineering, Environmental ; Engineering, Chemical
WOS IDWOS:000827389900004
Scopus ID2-s2.0-85133704844
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYuan, Zhen; Wen, Xiaofei; Nie, Liming; Zhao, Qingliang
Affiliation1.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, Department of Laboratory Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China
2.Cancer Center, Faculty of Health Sciences, Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau Special Administrative Region 999078, China
3.College of Materials, Xiamen University, Xiamen, 422 Siming Nan Road, 361005, China
4.Shenzhen Research Institute of Xiamen University, Shenzhen, 518063, China
5.Department of Medical Oncology, Xiang'an Hospital of Xiamen University, Xiamen, 2000 East Xiang'an Rd., Xiang'an, 361102, China
6.Department of Radiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medcine, Xiamen University, Xiamen, 361102, China
7.Capital Institute of Pediatrics, Beijing, 100020, China
8.Department of Interventional Radiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361000, China
9.Department of Interventional Radiology, Molecular Imaging Research Center (MIRC), The 4th Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China
10.Medical Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China
11.Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 119074, Singapore
12.Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore
13.Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Hong, Fengqiu,Geng, Xiaorui,Min, Guangzong,et al. Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer[J]. Chemical Engineering Journal,2022,449.
APA Hong, Fengqiu,Geng, Xiaorui,Min, Guangzong,Sun, Xiang,Zhang, Bei,Yao, Youliang,Li, Ronghui,Wang, Jing,Zhao, Hengyu,Guo, Peng,Yuan, Zhen,Wen, Xiaofei,Nie, Liming,Liu, Gang,Chen, Xiaoyuan,&Zhao, Qingliang.(2022).Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer.Chemical Engineering Journal,449.
MLA Hong, Fengqiu,et al."Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer".Chemical Engineering Journal 449(2022).
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