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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, Li Xing1; Liu, Yu Cheng2; Cho, Chang Hui3; Chen, Yi Rou4; Yang, Chan Shan5; Lu, Yin Lin2; Zhang, Zhiming2; Tsai, Yi Tseng1; Chin, Yu Cheng1; Yu, Jiashing6; Pan, Hsiu Min4; Jiang, Wei Rou1; Chia, Zi Chun1; Huang, Wei Shiang1; Chiu, Yu Lin3; Sun, Chun Kai6; Huang, Yu Ting7; Chen, Li Ming7; Wong, Ken Tsung7; Huang, Han Min5; Chen, Chih Hsin4; Chang, Yuan Jay3; Huang, Chih Chia1,8; Liu, Tzu Ming2
2022-07-06
Source PublicationJournal of Nanobiotechnology
ISSN1477-3155
Volume20Issue:1Pages:311
Abstract

The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

KeywordFluorescence Imaging Multiphoton Microscopy Near-infraRed Red Optoelectronic Material Photodynamic Therapy Polymer Theranostic
DOI10.1186/s12951-022-01515-5
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000825373800001
Scopus ID2-s2.0-85133547002
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChen, Chih Hsin; Chang, Yuan Jay; Huang, Chih Chia; Liu, Tzu Ming
Affiliation1.Department of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan
2.Institute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, SAR, 999078, Macao
3.Department of Chemistry, Tunghai University, Taichung, 40704, Taiwan
4.Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan
5.Institute and Undergraduate Program of Electro-Optical Engineering, National Taiwan Normal University, Taipei, 11677, Taiwan
6.Department of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan
7.Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan
8.Center of Applied Nanomedicine, National Cheng Kung University, Tainan, 70101, Taiwan
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yang, Li Xing,Liu, Yu Cheng,Cho, Chang Hui,et al. A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges[J]. Journal of Nanobiotechnology,2022,20(1):311.
APA Yang, Li Xing.,Liu, Yu Cheng.,Cho, Chang Hui.,Chen, Yi Rou.,Yang, Chan Shan.,Lu, Yin Lin.,Zhang, Zhiming.,Tsai, Yi Tseng.,Chin, Yu Cheng.,Yu, Jiashing.,Pan, Hsiu Min.,Jiang, Wei Rou.,Chia, Zi Chun.,Huang, Wei Shiang.,Chiu, Yu Lin.,Sun, Chun Kai.,Huang, Yu Ting.,Chen, Li Ming.,Wong, Ken Tsung.,...&Liu, Tzu Ming.(2022).A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges.Journal of Nanobiotechnology,20(1),311.
MLA Yang, Li Xing,et al."A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges".Journal of Nanobiotechnology 20.1(2022):311.
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