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Viral etiology among children hospitalized for acute respiratory tract infections and its association with meteorological factors and air pollutants: a time-series study (2014–2017) in Macao
Lei, Cheng1; Lou, Cheong Tat1; Io, King1; SiTou, Kin Ian1; Ip, Chong Pak1; HongJin, U.1; Pan, Baoquan1; Ung, Carolina Oi Lam2,3
2022-12-01
Source PublicationBMC Infectious Diseases
Volume22Issue:1
Abstract

Background: The associations between viral etiology of acute respiratory infections (ARI) with meteorological factors and air pollutants among children is not fully understood. This study aimed to explore the viral etiology among children hospitalized for ARI and the association of meteorological factors and air pollutants with children hospitalization due to viral ARI. Methods: Electronic health record data about children (aged between 1 month and 14 years) admitted for ARI at Kiang Wu Hospital in Macao between 2014 and 2017 was analyzed retrospectively. xMAP multiplex assays were used to detect viruses in the nasopharyngeal swab and distributed-lag nonlinear model (DLNM) was used to evaluate associations. Results: Among the 4880 cases of children hospitalization due to ARI, 3767 (77.2%) were tested positive for at least one virus and 676 (18%) exhibited multiple infections. Enterovirus (EV)/rhinovirus (HRV), adenovirus (ADV), respiratory syncytial virus (RSV) and influenza virus (IFV) were the most common viral pathogens associated with ARI and human bocavirus (hBOV) exhibited the highest multiple infection rates. Meteorological factors and air pollutants (PM, PM and NO) were associated with the risk of viral ARI hospitalization. The relative risk of viral infection increased with daily mean temperature but plateaued when temperature exceeded 23 °C, and increased when the relative humidity was < 70% and peaked at 50%. The effect of solar radiation was insignificant. Air pollutants (including PM, PM NO and O) showed strong and immediate effect on the incidence of viral infection. Conclusions: The effects of mean temperature, relative humidity and air pollutants should be taken into account when considering management of ARI among children.

KeywordAcute Respiratory Infections Air Pollutants Children Hospitalization Meteorological Factors
DOI10.1186/s12879-022-07585-y
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaInfectious Diseases
WOS SubjectInfectious Diseases
WOS IDWOS:000820251600001
Scopus ID2-s2.0-85133317435
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorUng, Carolina Oi Lam
Affiliation1.Department of Pediatrics, Kiang Wu Hospital, Macao
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao
3.Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao
Corresponding Author AffilicationUniversity of Macau;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Lei, Cheng,Lou, Cheong Tat,Io, King,et al. Viral etiology among children hospitalized for acute respiratory tract infections and its association with meteorological factors and air pollutants: a time-series study (2014–2017) in Macao[J]. BMC Infectious Diseases,2022,22(1).
APA Lei, Cheng,Lou, Cheong Tat,Io, King,SiTou, Kin Ian,Ip, Chong Pak,HongJin, U.,Pan, Baoquan,&Ung, Carolina Oi Lam.(2022).Viral etiology among children hospitalized for acute respiratory tract infections and its association with meteorological factors and air pollutants: a time-series study (2014–2017) in Macao.BMC Infectious Diseases,22(1).
MLA Lei, Cheng,et al."Viral etiology among children hospitalized for acute respiratory tract infections and its association with meteorological factors and air pollutants: a time-series study (2014–2017) in Macao".BMC Infectious Diseases 22.1(2022).
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