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Engineered extracellular vesicles and their mimetics for cancer immunotherapy
Liu, Chunping1,3,4; Wang, Yichao6; Li, Longmei1; He, Dongyue1; Chi, Jiaxin1; Li, Qin1; Wu, Yixiao2; Zhao, Yunxuan1; Zhang, Shihui1; Wang, Lei1; Fan, Zhijin2,5; Liao, Yuhui2
2022-09-01
Source PublicationJournal of Controlled Release
ISSN0168-3659
Volume349Pages:679-698
Abstract

Extracellular vesicles (EVs) are heterogeneous membranous vesicles secreted by living cells that are involved in many physiological and pathological processes as intermediaries for intercellular communication and molecular transfer. Recent studies have shown that EVs can regulate the occurrence and development of tumors by transferring proteins, lipids and nucleic acids to immune cells as signaling molecules. As a new diagnostic biomarker and drug delivery system, EVs have broad application prospects in immunotherapy. In addition, the breakthrough of nanotechnology has promoted the development and exploration of engineered EVs for immune-targeted therapy. Herein, we review the uniqueness of EVs in immune regulation and the engineering strategies used for immunotherapy and highlight the logic of their design through typical examples. The present situation and challenges of clinical transformation are discussed, and the development prospects of EVs in immunotherapy are proposed. The goal of this review is to provide new insights into the design of immune-regulatory EVs and expand their application in cancer immunotherapy.

KeywordCancer Immunotherapy Exosomes Extracellular Vesicles Immune Reprogramming Immunogenic Cell Death
DOI10.1016/j.jconrel.2022.05.062
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000848185500003
Scopus ID2-s2.0-85134885619
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Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510080, China
2.Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China
3.Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510080, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China
5.School of Medicine, South China University of Technology, Guangzhou, China
6.Department of Clinical Laboratory Medicine, Tai Zhou Central Hospital (Taizhou University Hospital), Taizhou, No.999 Donghai Road, Jiaojiang District, 318000, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, Chunping,Wang, Yichao,Li, Longmei,et al. Engineered extracellular vesicles and their mimetics for cancer immunotherapy[J]. Journal of Controlled Release,2022,349:679-698.
APA Liu, Chunping,Wang, Yichao,Li, Longmei,He, Dongyue,Chi, Jiaxin,Li, Qin,Wu, Yixiao,Zhao, Yunxuan,Zhang, Shihui,Wang, Lei,Fan, Zhijin,&Liao, Yuhui.(2022).Engineered extracellular vesicles and their mimetics for cancer immunotherapy.Journal of Controlled Release,349,679-698.
MLA Liu, Chunping,et al."Engineered extracellular vesicles and their mimetics for cancer immunotherapy".Journal of Controlled Release 349(2022):679-698.
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