Network analysis of psychiatric symptoms in schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)
Li, Wen1; Zhang, Qinge2; Tang, Yilang3,4; Park, Seon Cheol5; Park, Yongchon6; Yang, Shu Yu7; Chen, Lian Yu8; Lin, Shih Ku8,9; Najoan, Eunice10; Kallivayalil, Roy Abraham11; Viboonma, Kittisak12; Jamaluddin, Ruzita13; Javed, Afzal14; Thi Quynh Hoa, Duong15; Iida, Hitoshi16; Sim, Kang17; Swe, Thiha18; He, Yan Ling19; Ahmed, Helal Uddin20; De Alwis, Angelo21; Chiu, Helen F.K.22; Sartorius, Norman23; Tan, Chay Hoon24; Chong, Mian Yoon25; Shinfuku, Naotaka26; Avasthi, Ajit27; Grover, Sandeep27; Ungvari, Gabor S.28,29; Ng, Chee H.30; Xiang, Yu Tao31,32,33
Source PublicationAsian Journal of Psychiatry
AbstractAims: Schizophrenia is a major mental disorder with a wide range of psychiatric symptoms. This study explored the structure of psychiatric symptoms of schizophrenia using network analysis in a large representative Asian sample based on a survey of clinical features and treatment used in schizophrenia patients across 15 countries/territories in Asia. Methods: Data on the demographic characteristics and psychiatric symptoms in schizophrenia patients were extracted from the dataset of the fourth Research on Asia Psychotropic Prescription for Antipsychotics (REAP-AP) project. The presence of the following psychiatric symptoms including delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior, negative symptoms, social/occupational dysfunction, verbal aggression, physical aggression, and affective symptoms were analyzed. Results: A total of 3681 patients were included. The network analysis revealed that verbal aggression, hallucinations, and social/occupational dysfunction were the most central symptoms, while the connections between social/occupational dysfunction and verbal aggression, and between hallucinations and disorganized speech were the two strongest edges. There were significant gender differences in the network structure based on the network structure invariance test (M=0.74, P = 0.03) and invariant edge strength test. The positive correlation between verbal aggression and hallucinations was significantly stronger in the female network than that in the male network (P = 0.03), while a negative correlation between affective symptoms and negative symptoms was found in the female, but not the male network (P < 0.01). Conclusion: Central symptoms including verbal aggression, hallucinations, and socio-occupational dysfunction should be addressed in developing targeted treatment strategy for schizophrenia patients.
KeywordNetwork analysis Psychiatric symptoms Schizophrenia
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Scopus ID2-s2.0-85134595349
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, China, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, China
2.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3.Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, United States
4.Atlanta Veterans Affairs Medical Center, Decatur, United States
5.Department of Psychiatry, Hanyang University College of Medicine, Seoul, South Korea
6.Department of Psychiatry, Hanyang University, Seoul, South Korea
7.Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan
8.Kunming Prevention and Control Center, Taipei City Hospital; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taiwan
9.Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Linkou, Taiwan
10.Mintoharjo Hospital, Jakarta, Indonesia
11.Pushpagiri Institute of Medical Sciences, Tiruvalla, Kerala, India
12.Suanprung Psychiatric Hospital, Chian Mai, Thailand
13.Department of Psychiatry & Mental Health, Hospital Tuanku Fauziah, Kangar, Perlis, Malaysia
14.Pakistan Psychiatric Research Centre, Fountain House, Lahore, Pakistan
15.Thanh Hoa Provincial Psychiatric Hospital, Thanh Hoa, Viet Nam
16.Department of Psychiatry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
17.Institute of Mental Health, Buangkok Green Medical Park, Singapore
18.Department of Mental Health, University of Medicine, Magway, Myanmar
19.Department of Psychiatric Epidemiology, Shanghai Mental Health Center, Shanghai, China
20.National Institute of Mental Health, Dhaka, Bangladesh
21.National Institute of Mental Health, Angoda, Sri Lanka
22.Department of Psychiatry, Chinese University of Hong Kong, Hong Kong
23.Association for the Improvement of Mental Health Programs, Geneva, Switzerland
24.Department of Pharmacology, National University of Singapore, Singapore
25.Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung & Chang Gung University School of Medicine, Taoyuan, Taiwan
26.International Center for Medical Research, Kobe University School of Medicine, Kobe, Japan
27.Department of Psychiatry, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
28.University of Notre Dame Australia, Fremantle, Australia
29.Division of Psychiatry, Medical School, University of Western Australia, Perth, Australia
30.Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, Australia
31.Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao
32.Centre for Cognitive and Brain Sciences, University of Macau, Macao
33.Institute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao
Recommended Citation
GB/T 7714
Li, Wen,Zhang, Qinge,Tang, Yilang,et al. Network analysis of psychiatric symptoms in schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)[J]. Asian Journal of Psychiatry,2022,75.
APA Li, Wen.,Zhang, Qinge.,Tang, Yilang.,Park, Seon Cheol.,Park, Yongchon.,Yang, Shu Yu.,Chen, Lian Yu.,Lin, Shih Ku.,Najoan, Eunice.,Kallivayalil, Roy Abraham.,Viboonma, Kittisak.,Jamaluddin, Ruzita.,Javed, Afzal.,Thi Quynh Hoa, Duong.,Iida, Hitoshi.,Sim, Kang.,Swe, Thiha.,He, Yan Ling.,Ahmed, Helal Uddin.,...&Xiang, Yu Tao.(2022).Network analysis of psychiatric symptoms in schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP).Asian Journal of Psychiatry,75.
MLA Li, Wen,et al."Network analysis of psychiatric symptoms in schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP)".Asian Journal of Psychiatry 75(2022).
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