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Chemo-Phototherapy with Carfilzomib-Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis
Wu, Xuan1; Wang, Le2; Xu, Yan Neng1,3; Chen, Jian Li1; Luo, Kathy Qian4; Yuan, Ming Heng4; Li, Jie1; Yuan, Gang1,3; Gu, Ze Yun1; Jia, Xiao Hui1; Chen, Xiuping5; Zhu, Xiao Ming1; Jiang, Ruibin2
2022-07-01
Source PublicationSmall
ISSN1613-6810
Volume18Issue:29
Abstract

The design of nanomedicine for cancer therapy, especially the treatment of tumor metastasis has received great attention. Proteasome inhibition is accepted as a new strategy for cancer therapy. Despite being a big breakthrough in multiple myeloma therapy, carfilzomib (CFZ), a second-in-class proteasome inhibitor is still unsatisfactory for solid tumor and metastasis therapy. In this study, hollow titanium nitride (TiN) nanoshells are synthesized as a drug carrier of CFZ. The TiN nanoshells have a high loading capacity of CFZ, and their intrinsic inhibitory effect on autophagy synergistically enhances the activity of CFZ. Due to an excellent photothermal conversion efficiency in the second near-infrared (NIR-II) region, TiN nanoshell-based photothermal therapy further induces a synergistic anticancer effect. In vivo study demonstrates that TiN nanoshells readily drain into the lymph nodes, which are responsible for tumor lymphatic metastasis. The CFZ-loaded TiN nanoshell-based chemo-photothermal therapy combined with surgery offers a remarkable therapeutic outcome in greatly inhibiting further metastatic spread of cancer cells. These findings suggest that TiN nanoshells act as an efficient carrier of CFZ for realizing enhanced outcomes for proteasome inhibitor-based cancer therapy, and this work also presents a “combined chemo-phototherapy assisted surgery” strategy, promising for future cancer treatment.

KeywordAutophagy Carfilzomib Photothermal Therapy Proteasome Inhibitors Tin Nanoshells
DOI10.1002/smll.202200522
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000815017000001
Scopus ID2-s2.0-85132550455
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Institute of Chinese Medical Sciences
Corresponding AuthorZhu, Xiao Ming; Jiang, Ruibin
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, S.A.R., 999078, Macao
2.Shaanxi Key Laboratory for Advanced Energy Devices, Shaanxi Engineering Lab for Advanced Energy Technology, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an, 710119, China
3.Department of Intervention Radiology, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou, 646000, China
4.Faculty of Health Sciences, University of Macau, Taipa, S.A.R., 999078, Macao
5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, S.A.R., 999078, Macao
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wu, Xuan,Wang, Le,Xu, Yan Neng,et al. Chemo-Phototherapy with Carfilzomib-Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis[J]. Small,2022,18(29).
APA Wu, Xuan,Wang, Le,Xu, Yan Neng,Chen, Jian Li,Luo, Kathy Qian,Yuan, Ming Heng,Li, Jie,Yuan, Gang,Gu, Ze Yun,Jia, Xiao Hui,Chen, Xiuping,Zhu, Xiao Ming,&Jiang, Ruibin.(2022).Chemo-Phototherapy with Carfilzomib-Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis.Small,18(29).
MLA Wu, Xuan,et al."Chemo-Phototherapy with Carfilzomib-Encapsulated TiN Nanoshells Suppressing Tumor Growth and Lymphatic Metastasis".Small 18.29(2022).
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