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Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy
Shan, Shaobo1,2,3; Chen, Junge1,3; Sun, Yu4; Wang, Yongchao2,3; Xia, Bozhang3; Tan, Hong3; Pan, Changcun2; Gu, Guocan2; Zhong, Jie3; Qing, Guangchao3; Zhang, Yuxuan3; Wang, Jinjin3; Wang, Yufei3; Wang, Yi2; Zuo, Pengcheng2; Xu, Cheng2; Li, Fangzhou3; Guo, Weisheng5; Xu, Lijun1; Chen, Meiwan6; Fan, Yubo1; Zhang, Liwei1,2,7; Liang, Xing Jie3
2022-07-01
Source PublicationAdvanced Science
Volume9Issue:21
Abstract

Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53-induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, and inhibition of PPM1D expression in DIPG cells with PPM1D mutation effectively reduces the proliferation activity of tumor cells. Panobinostat effectively kills DIPG tumor cells, but its systemic toxicity and low blood–brain barrier (BBB) permeability limits its application. In this paper, a nano drug delivery system based on functionalized macrophage exosomes with panobinostat and PPM1D-siRNA for targeted therapy of DIPG with PPM1D mutation is prepared. The nano drug delivery system has higher drug delivery efficiency and better therapeutic effect than free drugs. In vivo and in vitro experimental results show that the nano drug delivery system can deliver panobinostat and siRNA across the BBB and achieve a targeted killing effect of DIPG tumor cells, resulting in the prolonged survival of orthotopic DIPG mice. This study provides new ideas for the delivery of small molecule drugs and gene drugs for DIPG therapy.

KeywordBlood–brain Barrier Diffuse Intrinsic Pontine Glioma Macrophage Exosomes Panobinostat Sirna Blood-brain Barrier
DOI10.1002/advs.202200353
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000797225100001
Scopus ID2-s2.0-85130249631
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhang, Liwei; Liang, Xing Jie
Affiliation1.Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering & School of Engineering Medicine & Shenzhen Institute of Beihang University, Beihang University, Beijing, 100083, China
2.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
3.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China
4.Pediatric Epilepsy Center, Peking University First Hospital, Beijing, No.1 Xi'an Men Street, Xicheng District, 100034, China
5.Department of Minimally Invasive Interventional Radiology, College of Biomedical Engineering & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
7.China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, 100070, China
Recommended Citation
GB/T 7714
Shan, Shaobo,Chen, Junge,Sun, Yu,et al. Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy[J]. Advanced Science,2022,9(21).
APA Shan, Shaobo.,Chen, Junge.,Sun, Yu.,Wang, Yongchao.,Xia, Bozhang.,Tan, Hong.,Pan, Changcun.,Gu, Guocan.,Zhong, Jie.,Qing, Guangchao.,Zhang, Yuxuan.,Wang, Jinjin.,Wang, Yufei.,Wang, Yi.,Zuo, Pengcheng.,Xu, Cheng.,Li, Fangzhou.,Guo, Weisheng.,Xu, Lijun.,...&Liang, Xing Jie.(2022).Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy.Advanced Science,9(21).
MLA Shan, Shaobo,et al."Functionalized Macrophage Exosomes with Panobinostat and PPM1D-siRNA for Diffuse Intrinsic Pontine Gliomas Therapy".Advanced Science 9.21(2022).
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