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Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver
Zhao, Yi1; Tan, De Chao1; Peng, Bo1; Yang, Lin1; Zhang, Si Yuan1; Shi, Rui Peng1; Chong, Cheong Meng1; Zhong, Zhang Feng1; Wang, Sheng Peng1; Liang, Qiong Lin2; Wang, Yi Tao1
2022-06-01
Source PublicationMolecules
Volume27Issue:12
Abstract

Eucommia ulmoides Oliver (E. ulmoides) is a popular medicinal herb and health supplement in China, Japan, and Korea, and has a variety of pharmaceutical properties. The neuroendocrine– immune (NEI) network is crucial in maintaining homeostasis and physical or psychological functions at a holistic level, consistent with the regulatory theory of natural medicine. This review aims to systematically summarize the chemical compositions, biological roles, and pharmacological properties of E. ulmoides to build a bridge between it and NEI-associated diseases and to provide a perspective for the development of its new clinical applications. After a review of the literature, we found that E. ulmoides has effects on NEI-related diseases including cancer, neurodegenerative disease, hyperlipidemia, osteoporosis, insomnia, hypertension, diabetes mellitus, and obesity. However, clinical studies on E. ulmoides were scarce. In addition, E. ulmoides derivatives are diverse in China, and they are mainly used to enhance immunity, improve hepatic damage, strengthen bones, and lower blood pressure. Through network pharmacological analysis, we uncovered the possibility that E. ulmoides is involved in functional interactions with cancer development, insulin resistance, NAFLD, and various inflammatory pathways associated with NEI diseases. Overall, this review suggests that E. ulmoides has a wide range of applications for NEI-related diseases and provides a direction for its future research and development.

KeywordCancer Eucommia UlmoidE. OlivE. (E. UlmoidE.) Natural Products Network Pharmacology Neuroendocrine–immune
DOI10.3390/molecules27123697
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000816349800001
Scopus ID2-s2.0-85131735244
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLiang, Qiong Lin; Wang, Yi Tao
Affiliation1.Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
2.MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Department of Chemistry, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhao, Yi,Tan, De Chao,Peng, Bo,et al. Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver[J]. Molecules,2022,27(12).
APA Zhao, Yi,Tan, De Chao,Peng, Bo,Yang, Lin,Zhang, Si Yuan,Shi, Rui Peng,Chong, Cheong Meng,Zhong, Zhang Feng,Wang, Sheng Peng,Liang, Qiong Lin,&Wang, Yi Tao.(2022).Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver.Molecules,27(12).
MLA Zhao, Yi,et al."Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver".Molecules 27.12(2022).
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