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Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages
RutingZhong1; Lingchao Miao1; Haolin Zhang1; Lihua Tan1; Yuxin Zhao1; Yanbei Tu1; Miguel Angel Priet3; Jesus Simal-Gandara3; Lei Chen2; Chengwei He1; Hui Cao2,3
2022-07
Source PublicationCurrent Research in Food Science
ISSN2665-9271
Volume5Issue:2022
Abstract

Fisetin (Fis), quercetin (Que), and myricetin (Myr) are flavonols with similar structure but different number of hydroxyl groups. The present research focused on the anti-inflammatory effect of these three flavonols in lipopolysaccharide-stimulated RAW264.7 cells. The number and site of hydroxyl group in flavonols obviously affected their anti-inflammation activity. These flavonols suppressed the overproduction of nitric oxide. Fis showed the best activity with an inhibition rate of 52% at 20 μM. Moreover, the flavonols reduced the levels of ROS, TNF-α, and IL-6. The mechanistic study showed that they inhibited the activation of NF-κB and MAPK pathways by suppressing the phosphorylation of IκBα, p65, JNKERK, p38, MEK, and reducing the nuclear translocation of NF-κB p65. In addition, the metabolism of the flavonols was examined. The results indicated that Fis was both methylated and glucuronidated. Que and Myr were mainly transformed into methylated products. This study highlights the anti-inflammatory activity of flavonols, particularly Fis, which has the potential for the prevention or treatment of inflammation as an adjuvant medicine or food additive.

KeywordFisetin Quercetin Myricetin Anti-inflammation Nf-κb Mapk
DOI10.1016/j.crfs.2022.07.007
URLView the original
Indexed BySCIE
Language英語English
PublisherElsevier
Fulltext Access
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRutingZhong; Chengwei He; Hui Cao
Affiliation1.University of Macau
2.Guangdong Ocean University
3.Universidade de Vigo
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
RutingZhong,Lingchao Miao,Haolin Zhang,et al. Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages[J]. Current Research in Food Science,2022,5(2022).
APA RutingZhong,Lingchao Miao,Haolin Zhang,Lihua Tan,Yuxin Zhao,Yanbei Tu,Miguel Angel Priet,Jesus Simal-Gandara,Lei Chen,Chengwei He,&Hui Cao.(2022).Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages.Current Research in Food Science,5(2022).
MLA RutingZhong,et al."Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages".Current Research in Food Science 5.2022(2022).
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