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Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons
Linqiang Xu1; Hua Yu2; Shaoping Yin1; Ruixia Zhang1; Yudan Zhou1; Juan Li1
Source PublicationJournal of Nanoparticle Research

The Ginsenoside Rh2 (Rh2) has been shown to possess anti-cancer properties both in vitro and in vivo. However, the poor bioavailability and fast plasma elimination limit the further clinical applications of Rh2 for cancer treatments. In the present study, three types of Rh2-loaded liposomes including Rh2-loaded normal liposome (Rh2-LP), Rh2-loaded cationic liposome (Rh2-CLP), and Rh2-loaded Methoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) liposome (Rh2-PLP) have been optimized and prepared with mean particle size of 80-125 nm. Compared to Rh2-LP, surface modifications with mPEG or octadecylamine significantly improve the physicochemical and biological properties both in vitro and in vivo. Moreover, PLP presented better tumor accumulation of the fluorescent cyanine dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) in HepG2-xenografted nude mice than CLP (1.3-fold) or LP (1.6-fold) and prolong the resident time of DiR in tumor and organs (more than 24 h). The in vivo anti-cancer efficacy assessments indicate that Rh2-PLP presents the most activity on suppressing tumor growth in HepG2-xenografted mice than Rh2-LP and Rh2-CLP and without any significant toxicity. Our results indicate that mPEG-PLA modified liposome should be a potential and promising strategy to enhance the therapeutic index for anti-cancer agents.

KeywordGinsenoside Rh2 Liposomes Mpegpla Biodistribution Anti-cancer Drug Delivery Nanomedicine Health Effects
Indexed BySCIE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000363255800001
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorJuan Li
Affiliation1.Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, People’s Republic of China
2.Institute of Chinese Medical Sciences, University of Macao, Macao SAR, People’s Republic of China
Recommended Citation
GB/T 7714
Linqiang Xu,Hua Yu,Shaoping Yin,et al. Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons[J]. Journal of Nanoparticle Research,2015,17(10).
APA Linqiang Xu,Hua Yu,Shaoping Yin,Ruixia Zhang,Yudan Zhou,&Juan Li.(2015).Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons.Journal of Nanoparticle Research,17(10).
MLA Linqiang Xu,et al."Liposome-based delivery systems for ginsenoside Rh2: in vitro and in vivo comparisons".Journal of Nanoparticle Research 17.10(2015).
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