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Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples
Yin, Shi Jun1; Zhou, Xi1; Peng, Li Jing1; Li, Fang2; Zheng, Guo Can2; Yang, Feng Qing1; Hu, Yuan Jia3
2022
Source PublicationJournal of Pharmaceutical Analysis
ISSN2095-1779
AbstractAn innovative sandwich-structural Fe-based metal-organic framework magnetic material (FeO@SW-MIL-101-NH) was fabricated using a facile solvothermal method. The characteristic properties of the material were investigated by field emission scanning electron microscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, vibrating sample magnetometry, and Brunauer-Emmett-Teller measurements. FeO@SW-MIL-101-NH is associated with advantages, such as robust magnetic properties, high specific surface area, and satisfactory storage stability, as well as good selective recognition ability for chlorogenic acid (CA) and its metabolites via chelation, hydrogen bonding, and π-interaction. The results of the static adsorption experiment indicated that FeO@SW-MIL-101-NH possessed a high adsorption capacity toward CA and its isomers, cryptochlorogenic acid (CCA) and neochlorogenic acid (NCA), and the adsorption behaviors were fitted using the Langmuir adsorption isotherm model. Then, a strategy using magnetic solid-phase extraction (MSPE) and ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF MS) was developed and successfully employed for the selective pre-concentration and rapid identification of CA metabolites in rat plasma, urine, and feces samples. This work presents a prospective strategy for the synthesis of magnetic adsorbents and the high-efficiency pretreatment of CA metabolites.
KeywordChlorogenic acid Magnetic solid-phase extraction Metabolic pathway Metal-organic framework Sandwich structure
DOI10.1016/j.jpha.2022.01.002
URLView the original
Language英語English
Scopus ID2-s2.0-85134160249
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 401331, China
2.Analytical and Testing Center, Chongqing University, Chongqing, 401331, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China
Recommended Citation
GB/T 7714
Yin, Shi Jun,Zhou, Xi,Peng, Li Jing,et al. Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples[J]. Journal of Pharmaceutical Analysis,2022.
APA Yin, Shi Jun,Zhou, Xi,Peng, Li Jing,Li, Fang,Zheng, Guo Can,Yang, Feng Qing,&Hu, Yuan Jia.(2022).Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples.Journal of Pharmaceutical Analysis.
MLA Yin, Shi Jun,et al."Preparation of Fe3O4@SW-MIL-101-NH2 for selective pre-concentration of chlorogenic acid metabolites in rat plasma, urine, and feces samples".Journal of Pharmaceutical Analysis (2022).
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