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Biomedical Analytics of Four Chinese Medicinals in Treatment of Insomnia Based on Network Pharmacology
Deng, Qiyue1,2; Huang, Libing3; Yu, Fanjun1,2; Lin, Jiahui1; Hu, Lijuan4; Zhao, Jing5; Pan, Litao6; Kui, Yu2,7; Wu, Shiheng2,7
2022
Source PublicationBioMed Research International
ISSN2314-6133
Volume2022
AbstractAim. Our aim is to recommend the appropriate Chinese medicinals in clinical treatment of insomnia, which are suānzǎorén (Semen Ziziphi Spinosae), chuānxiōng (Rhizoma Chuanxiong), fúlíng (Poria), and báisháo (Radix Paeoniae Alba). Method. Based on network pharmacology, the active molecules and mechanism of these four Chinese medicinals treating insomnia were sought and analyzed. The components of the four Chinese medicinals with potential activity were collected and screened. Moreover, the recollected human disease-related targets were correlated through Cytoscape 3.8.2, and the network diagram of drug component disease targets was drawn. Based on the human protein-protein interaction database, the above network diagram was imported to establish the protein-protein interaction (PPI) and composite target pathway (C-T-P) networks. After selecting important information, the pathway analysis was carried out to show the biological process, core target, and core pathway of insomnia treatment. Result. In this study, 44 active components and 81 drug-disease common targets were obtained; 307 key targets were found in the PPI network; a core cluster composed of 14 nodes and 50 functional associations was found. Conclusion. In summary, the four Chinese medicinals' effective components and main mechanism of in the treatment of insomnia may be related to their participation in the regulation of endocrine. Compared with the existing network pharmacological analysis results of SuānZǎoRénTāng (Sour Jujube Decoction), which is commonly used in insomnia, they have similar effects on the immune system and HPA axis, while the focus of the four Chinese medicinals is mainly on endocrine regulation, and SuānZǎoRénTāng (Sour Jujube Decoction) is mainly on anti-inflammatory effect.
DOI10.1155/2022/9414262
URLView the original
Language英語English
Scopus ID2-s2.0-85133147118
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Guangzhou University of Chinese Medicine, Guangzhou, China
2.The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, China
3.Guangdong Kanghe Research Center of Chronic Disease, Guangzhou, China
4.Zhejiang Chinese Medical University, Hangzhou, China
5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macao
6.The First Affiliated Hospital, Shenzhen University, Shenzhen, China
7.The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, Guangzhou, China
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GB/T 7714
Deng, Qiyue,Huang, Libing,Yu, Fanjun,et al. Biomedical Analytics of Four Chinese Medicinals in Treatment of Insomnia Based on Network Pharmacology[J]. BioMed Research International,2022,2022.
APA Deng, Qiyue,Huang, Libing,Yu, Fanjun,Lin, Jiahui,Hu, Lijuan,Zhao, Jing,Pan, Litao,Kui, Yu,&Wu, Shiheng.(2022).Biomedical Analytics of Four Chinese Medicinals in Treatment of Insomnia Based on Network Pharmacology.BioMed Research International,2022.
MLA Deng, Qiyue,et al."Biomedical Analytics of Four Chinese Medicinals in Treatment of Insomnia Based on Network Pharmacology".BioMed Research International 2022(2022).
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