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Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics
Zhen Yang1,2; Yunlu Dai3; Lingling Shan2; Zheyu Shen2; Zhantong Wang2; Bryant C. Yung2; Orit Jacobson2; Yijing Liu2; Wei Tang2; Sheng Wang2; Lisen Lin2; Gang Niu2; Pintong Huang1; Xiaoyuan Chen2
Source PublicationNanoscale Horizons

A Pt prodrug polyphenol and gadolinium ion loaded cancer theranostics nanoplatform based on a mild acidic pH and thermal sensitive polymer was designed for photoacoustic (PA)/magnetic resonance (MR)/positron emission tomography (PET) multimodal imaging-guided chemo-photothermal combination therapy. The Pt drug release can be controlled by tumour-specific acidic pH and heat generated by external NIR irradiation. The nanoparticles were stable under normal physiological environments and released the drug under the acidic pH of tumours and NIR laser irradiation, which can reduce the side effects of the drug to normal organs. Moreover, the MR signal can be significantly enhanced (B3-fold increase in T1 relaxivity) under the acidic tumour microenvironment, which is favorable for cancer diagnosis. The nanoparticles exhibited excellent tumour accumulation and led to complete tumour eradication with low power NIR laser irradiation. This promising approach provides a new avenue for imaging-guided combination therapy.

Indexed BySCIE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000461558200009
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Cited Times [WOS]:59   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYunlu Dai; Pintong Huang; Xiaoyuan Chen
Affiliation1.Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, P. R. China.
2.Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA
3.Faculty of Health Sciences, University of Macau, Macau, SAR 999078, P. R. China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhen Yang,Yunlu Dai,Lingling Shan,et al. Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics[J]. Nanoscale Horizons,2019,4(2):426-433.
APA Zhen Yang,Yunlu Dai,Lingling Shan,Zheyu Shen,Zhantong Wang,Bryant C. Yung,Orit Jacobson,Yijing Liu,Wei Tang,Sheng Wang,Lisen Lin,Gang Niu,Pintong Huang,&Xiaoyuan Chen.(2019).Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics.Nanoscale Horizons,4(2),426-433.
MLA Zhen Yang,et al."Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics".Nanoscale Horizons 4.2(2019):426-433.
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