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Mouse Strain– and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit
Haoran Chen1,2; Yu-Cheng Liu1; Zhiming Zhang1; Moxin Li1; Lidong Du1; Pei-Chun Wu1; Wai-How Chong1; Fuzeng Ren2; Weiming Zheng3; Tzu-Ming Liu1,4
2022
Source PublicationFrontiers in Chemistry
ISSN2296-2646
Volume10Pages:944556
Abstract

Remarkable advancement has been made in the application of nanoparticles (NPs) for cancer therapy. Although NPs have been favorably delivered into tumors by taking advantage of the enhanced permeation and retention (EPR) effect, several physiological barriers present within tumors tend to restrict the diffusion of NPs. To overcome this, one of the strategies is to design NPs that can reach lower size limits to improve tumor penetration without being rapidly cleared out by the body. Several attempts have been made to achieve this, such as selecting appropriate nanocarriers and modifying surface properties. While many studies focus on the optimal design of NPs, the influence of mouse strains on the effectiveness of NPs remains unknown. Therefore, this study aimed to assess whether the vascular permeability of NPs near the lower size limit differs among mouse strains. We found that the vessel permeability of dextran NPs was size-dependent and dextran NPs with a size below 15 nm exhibited leakage from postcapillary venules in all strains. Most importantly, the leakage rate of 8-nm fluorescein isothiocyanate dextran was significantly higher in the BALB/c mouse strain than in other strains. This strain dependence was not observed in slightly positive TRITC-dextran with comparable sizes. Our results indicate that the influence on mouse strains needs to be taken into account for the evaluation of NPs near the lower size limit.

DOIhttps://doi.org/10.3389/fchem.2022.944556
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWeiming Zheng; Tzu-Ming Liu
Affiliation1.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
2.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China
3.Translational Medicine R&D Center, Zhuhai UM Science and Technology Research Institute, Zhuhai, China
4.MOE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences;  University of Macau
Recommended Citation
GB/T 7714
Haoran Chen,Yu-Cheng Liu,Zhiming Zhang,et al. Mouse Strain– and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit[J]. Frontiers in Chemistry,2022,10:944556.
APA Haoran Chen,Yu-Cheng Liu,Zhiming Zhang,Moxin Li,Lidong Du,Pei-Chun Wu,Wai-How Chong,Fuzeng Ren,Weiming Zheng,&Tzu-Ming Liu.(2022).Mouse Strain– and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit.Frontiers in Chemistry,10,944556.
MLA Haoran Chen,et al."Mouse Strain– and Charge-Dependent Vessel Permeability of Nanoparticles at the Lower Size Limit".Frontiers in Chemistry 10(2022):944556.
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