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A Novel Polysaccharide From Chuanminshen violaceum and Its Protective Effect Against Myocardial Injury
He, Peng1; Zhang, Mi1; Zhao, Meng2; Zhang, Mengyao1; Ma, Benxu3; Lv, Hongyu1; Han, Yantao1; Wu, Dingtao4; Zhong, Zhangfeng5; Zhao, Wenwen1,5
2022-07-14
Source PublicationFrontiers in Nutrition
Volume9
Abstract

We isolated and purified a novel polysaccharide from the root of Chuanminshen violaceum, namely, Chuanminshen violaceumis polysaccharide (CVP) and confirmed its structure and molecular weight. Furthermore, in vivo experiment, CVP’s protective effect against myocardial ischemia-reperfusion (I/R) injury in mice was evidenced by significantly reducing I/R-induced myocardial infarction (MI) size, decreasing the secretion of heart damage biomarkers, and improving cardiac function. Then, the myocardial anoxia/reoxygenation (A/R) injury model was established to mimic reperfusion injury. Noticeably, ferroptosis was the major death manner for A/R-damaged H9c2 cells. Meanwhile, CVP significantly inhibited ferroptosis by decreasing intracellular Fe level, enhancing GPX4 expression, and suppressing lipid peroxidation to confront A/R injury. In conclusion, CVP, with a clear structure, ameliorated I/R injury by inhibiting ferroptosis.

KeywordAntioxidant Activity Chuanmingshen Violacenm Ferroptosis Myocardial Ischemia-reperfusion Polysaccharide
DOI10.3389/fnut.2022.961182
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNutrition & Dietetics
WOS SubjectNutrition & Dietetics
WOS IDWOS:000834044700001
Scopus ID2-s2.0-85135077452
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhong, Zhangfeng; Zhao, Wenwen
Affiliation1.School of Basic Medical Sciences, Qingdao University, Qingdao, China
2.School of Nursing, Qingdao University, Qingdao, China
3.The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, China
4.Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), Sichuan Engineering Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu, China
5.Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Zhuhai, Macao
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
He, Peng,Zhang, Mi,Zhao, Meng,et al. A Novel Polysaccharide From Chuanminshen violaceum and Its Protective Effect Against Myocardial Injury[J]. Frontiers in Nutrition,2022,9.
APA He, Peng,Zhang, Mi,Zhao, Meng,Zhang, Mengyao,Ma, Benxu,Lv, Hongyu,Han, Yantao,Wu, Dingtao,Zhong, Zhangfeng,&Zhao, Wenwen.(2022).A Novel Polysaccharide From Chuanminshen violaceum and Its Protective Effect Against Myocardial Injury.Frontiers in Nutrition,9.
MLA He, Peng,et al."A Novel Polysaccharide From Chuanminshen violaceum and Its Protective Effect Against Myocardial Injury".Frontiers in Nutrition 9(2022).
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