UM  > INSTITUTE OF COLLABORATIVE INNOVATION
Affiliated with RCfalse
Status已發表Published
The role of oxytocin in modulating self–other distinction in human brain: A pharmacological fMRI study
Wang, Yuanchen; Wang, Ruien; Wu, Haiyan
2022-04-28
Source PublicationCerebral Cortex
Abstract

Self–other distinction is crucial for human interaction. Although with conflicting results, studies have found that oxytocin (OT) sharpens the self–other perceptual boundary. However, little is known about the effect of OT on self–other perception, especially its neural basis. Moreover, it is unclear whether OT influences self–other discrimination when the other is a child or an adult. This double-blind, placebo-controlled study investigated the effect of OT on self-face perception at the behavioral and neural levels. For the stimuli, we morphed participants’ faces and child or adult strangers’ faces, resulting in 4 conditions. After treatment with either OT or placebo, participants reported whether a stimulus resembled themselves while being scanned using functional magnetic resonance imaging (fMRI). Behavioral results showed that people judged adult-morphed faces better than child-morphed faces. Moreover, fMRI results showed that the OT group exhibited increased activity in visual areas and the inferior frontal gyrus for self-faces. This difference was more pronounced in the adult-face condition. In multivariate fMRI and region of interest analyses, better performance in the OT group indicated that OT increased self–other distinction, especially for adult faces and in the left hemisphere. Our study shows a significant effect of OT on self-referential processes, proving the potential effect of OT on a left hemisphere self-network.

KeywordFace Fmri Oxytocin Self-other Distinction Self-resemblance
DOI10.1093/cercor/bhac167
URLView the original
Indexed By核心期刊
Language英語English
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
Fulltext Access
Citation statistics
Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorWu, Haiyan
Recommended Citation
GB/T 7714
Wang, Yuanchen,Wang, Ruien,Wu, Haiyan. The role of oxytocin in modulating self–other distinction in human brain: A pharmacological fMRI study[J]. Cerebral Cortex,2022.
APA Wang, Yuanchen,Wang, Ruien,&Wu, Haiyan.(2022).The role of oxytocin in modulating self–other distinction in human brain: A pharmacological fMRI study.Cerebral Cortex.
MLA Wang, Yuanchen,et al."The role of oxytocin in modulating self–other distinction in human brain: A pharmacological fMRI study".Cerebral Cortex (2022).
Files in This Item: Download All
File Name/Size Publications Version Access License
The role of oxytocin(2039KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Yuanchen]'s Articles
[Wang, Ruien]'s Articles
[Wu, Haiyan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Yuanchen]'s Articles
[Wang, Ruien]'s Articles
[Wu, Haiyan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Yuanchen]'s Articles
[Wang, Ruien]'s Articles
[Wu, Haiyan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: The role of oxytocin in modulating self–other distinction in human brain a pharmacological fMRI study.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.