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Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapyostics
Qing Dan1,2; Zhen Yuan3; Si Zheng1,2; Huanrong Ma1; Wanxian Luo1; Li Zhang1; Ning Su1; Dehong Hu1; Zonghai Sheng2; Yingjia Li1
2022-06-28
Source PublicationPharmaceutics
ISSN1999-4923
Volume14Issue:8Pages:1645-1-1645-17
Abstract

Photodynamic therapy (PDT) under fluorescence imaging as a selective and non-invasive treatment approach has been widely applied for the therapy of cancer and bacterial infections. However, its treatment efficiency is hampered by high background fluorescence in the first near-infrared window (NIR-I, 700–900 nm) and oxygen-dependent photosensitizing activity of traditional photosensitizers. In this work, we employ gold nanoclusters (BSA@Au) with the second near-infrared (NIR-II, 1000–1700 nm) fluorescence and catalase-like activity as alternative photosensitizers to realize highly efficient PDT. The bright NIR-II fluorescence of BSA@Au enables the visualization of PDT for tumor with a high signal-to-background ratio (SBR = 7.3) in 4T1 tumor-bearing mouse models. Furthermore, the catalase-like activity of BSA@Au endows its oxygen self-supplied capability, contributing to a five-fold increase in the survival period of tumor-bearing mice receiving boosted PDT treatment compared to that of the control group. Moreover, we further demonstrate that BSA@Au-based PDT strategy can be applied to treat bacterial infections. Our studies show the great potential of NIR-II BSA@Au as a novel photosensitizer for boosted PDT against cancer and bacterial infections. 

KeywordPhotodynamic Therapy Nir-ii Fluorescence Gold Nanoclusters Hypoxia Nanozyme Cancer Theranostics
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
PublisherMDPI
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZonghai Sheng; Yingjia Li
Affiliation1.Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University
2.Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences,
3.Faculty of Health Sciences, University of Macau
Recommended Citation
GB/T 7714
Qing Dan,Zhen Yuan,Si Zheng,et al. Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapyostics[J]. Pharmaceutics,2022,14(8):1645-1-1645-17.
APA Qing Dan,Zhen Yuan,Si Zheng,Huanrong Ma,Wanxian Luo,Li Zhang,Ning Su,Dehong Hu,Zonghai Sheng,&Yingjia Li.(2022).Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapyostics.Pharmaceutics,14(8),1645-1-1645-17.
MLA Qing Dan,et al."Gold Nanoclusters-Based NIR-II Photosensitizers with Catalase-like Activity for Boosted Photodynamic Therapyostics".Pharmaceutics 14.8(2022):1645-1-1645-17.
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