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Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma
Xiaoju Men1; Xiaoru iGeng1; Zhe Zhang1; Haibin Chen1; Meng Du1; Zhiyi Chen1; Gang Liu1; Changfeng Wu1; Zhen Yuan1,2
2022-08
Source PublicationMaterials Today Bio
ISSN2590-0064
Volume16Pages:100383
Abstract

Glioma with very short medium survival time consists of 80% of primary malignant types of brain tumors. The
unique microenvironment such as the existence of the blood-brain barrier (BBB) makes the glioma theranostics
exhibit low sensitivity in diagnosis, a poor prognosis and low treatment efficacy. Therefore, the development of
multifunctional nanoplatform that can cross BBB and target the glioma is essential for the high-sensitivity
detection and ablation of cancer cells. In this study, C6 cell membrane-coated conjugated polymer dots (Pdots-
C6) were constructed for targeted glioma tumor detection. As a new kind of biomimetic and biocompatible
nanoprobes, Pdots-C6 preserve the complex biological functions of natural cell membranes while possessing
physicochemical properties for NIR-II fluorescence imaging of glioma. After encapsulating C6 cell membrane on
the surface of conjugated Pdots, Pdots-C6 exhibited the most favorable specific targeting capabilities in vitro and
in vivo. In particular, this pilot study demonstrates that biomimetic nanoparticles offer a potential tool to enhance
specific targeting to the brain, hence improving glioma tumor detection accuracy.

KeywordCell Membrane Coated Nanoparticles ,Second Near-infrared Imaging, Conjugated Polymers Polymer Dot, Brain Tumor
DOI100383 2
Indexed BySCIE
Language英語English
WOS Research AreaEngineering, Biomedical ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000843486300003
PublisherElsevier
Fulltext Access
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Faculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorZhen Yuan
Affiliation1.Faculty of Health Sciences, University of Macau
2.Centre for Cognitive and Brain Sciences, University of Macau
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xiaoju Men,Xiaoru iGeng,Zhe Zhang,et al. Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma[J]. Materials Today Bio,2022,16:100383.
APA Xiaoju Men,Xiaoru iGeng,Zhe Zhang,Haibin Chen,Meng Du,Zhiyi Chen,Gang Liu,Changfeng Wu,&Zhen Yuan.(2022).Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma.Materials Today Bio,16,100383.
MLA Xiaoju Men,et al."Biomimetic semiconducting polymer dots for highly specific NIR-II fluorescence imaging of glioma".Materials Today Bio 16(2022):100383.
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