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Activatable Small‐Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper (II) in Mice with Alzheimer's Disease
Shichao Wang1; Zonghai Sheng2; Zhenguo Yang1; Dehong Hu2; Xiaojing Long1; Gang Feng,1; Yubin Liu1; Zhen Yuan1; Jingjing Zhang2; Hairong Zheng2; Xuanjun Zhang1
2019-02
Source PublicationAngewandte Chemie International Edition
ISSN0570-0833
Volume58Issue:36Pages:12415-12419
Abstract

Copper enrichment in the brain is highly related to AlzheimerQs disease (AD) pathogenesis, but in vivo tracing of Cu2+ in the brain by imaging techniques is still a great challenge. In this work, we developed a series of activatable photoacoustic (PA) probes with low molecular weights (less than 438 Da), RPS1–RPS4, which can specifically chelate with Cu2+ to form radicals with turn-on PA signals in the nearinfrared (NIR) region.Introducing the electron-donating group N,N-dimethylaniline into the probe was found to significantly enhance the radical stability and PA intensity. The best probe in the series, RPS1, showed a fast response (within seconds) to Cu2+ with high selectivity and a low PA detection limit of 90.9 nm. Owing to the low molecular weight and amphiphilic structure, RPS1 could effectively cross the blood–brain barrier (BBB) and thus allowed us, for the first time, to visualize Cu 2+ in vivo via PA imaging in the brains of AD mice. 

KeywordPhotodynamic Therapy Nir-ii Fluorescence Gold Nanoclusters Hypoxia Nanozyme Cancer Theranostics
Indexed BySCIE
Language英語English
WOS Research AreaChemistry, Multidisciplinary
PublisherWiley
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding AuthorZonghai Sheng; Xuanjun Zhang
Affiliation1.Faculty of Health Sciences, University of Macau
2.SIAT, CAS
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Shichao Wang,Zonghai Sheng,Zhenguo Yang,et al. Activatable Small‐Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper (II) in Mice with Alzheimer's Disease[J]. Angewandte Chemie International Edition,2019,58(36):12415-12419.
APA Shichao Wang,Zonghai Sheng,Zhenguo Yang,Dehong Hu,Xiaojing Long,Gang Feng,,Yubin Liu,Zhen Yuan,Jingjing Zhang,Hairong Zheng,&Xuanjun Zhang.(2019).Activatable Small‐Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper (II) in Mice with Alzheimer's Disease.Angewandte Chemie International Edition,58(36),12415-12419.
MLA Shichao Wang,et al."Activatable Small‐Molecule Photoacoustic Probes that Cross the Blood–Brain Barrier for Visualization of Copper (II) in Mice with Alzheimer's Disease".Angewandte Chemie International Edition 58.36(2019):12415-12419.
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