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Monolithic Multiband CMUTs for Photoacoustic Computed Tomography With In VivoBiological Tissue Imaging
Sio Hang Pun1; Yuanyu Yu2,3; Jian Zhang4; Jiujiang Wang1,2; Ching-Hsiang Cheng,5; Kin Fong Lei6,7; Zhen Yuan8; Peng Un Mak2
2018-03
Source PublicationIEEE transactions on ultrasonics, ferroelectrics, and frequency control
ISSN0885-3010
Volume65Issue:3Pages:465-475
Abstract

Among the biomedical imaging modalities, photoacoustic computed tomography (PACT) was one of the emerging hybrid techniques in recent years. In designing the PACT imaging system, a finite-bandwidth transducer is one of the limited factors for the overall performance. As the target size is inversely proportional to the dominant frequency components of the generated photoacoustic (PA) signal, a broad bandwidth transducer is desired for different scales' imaging. In this paper, a monolithic multiband capacitive micromachined ultrasonic transducer (CMUT) array was designed and fabricated for the reception of the wideband PA signals so as to provide high-resolution images with high-frequency CMUT arrays and present the high signal-to-noise-ratio major structure with low-frequency CMUT arrays. To demonstrate its performance, a phantom experiment was conducted to show and evaluate the various qualities of multiresolution images. In addition, an in vivo mouse model experiment was also carried out for revealing the multiscale PA imaging capability with the multiband CMUTs on biological tissues. From the obtained results, the images from different CMUT arrays could show the structures of the mouse brain in different scales. In addition, the images from the high-frequency CMUT arrays were able to reveal the major blood vasculatures, whereas the images from low-frequency CMUT arrays showed the gross macroscopic anatomy of the brain with higher contrast.

KeywordCapacitive Micromachined Ultrasonic Transducer (Cmut) Multiband Cmut Photoacoustic Computed Tomography (Pact)
DOI10.1109/TUFFC.2018.2792784
Indexed BySCIE
Language英語English
WOS Research AreaAcoustics ; Engineering
WOS SubjectAcoustics ; Engineering, Electrical & Electronic
PublisherIEEE
Fulltext Access
Citation statistics
Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhen Yuan
Affiliation1.State Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macau, 999078, Macao
2.Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, 999078, Macao
3.School of Information Engineering, Lingnan Normal University, Zhanjiang, 524048, China
4.Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 510182, China
5.School of Automotive Engineering, Wuhan University of Technology, Wuhan, 430070, China
6.Graduate Institute of Medical Mechatronics, Chang Gung University, Taoyuan, 33302, Taiwan
7.Department of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan
8.Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau, 999078, Macao
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Sio Hang Pun,Yuanyu Yu,Jian Zhang,et al. Monolithic Multiband CMUTs for Photoacoustic Computed Tomography With In VivoBiological Tissue Imaging[J]. IEEE transactions on ultrasonics, ferroelectrics, and frequency control,2018,65(3):465-475.
APA Sio Hang Pun,Yuanyu Yu,Jian Zhang,Jiujiang Wang,Ching-Hsiang Cheng,,Kin Fong Lei,Zhen Yuan,&Peng Un Mak.(2018).Monolithic Multiband CMUTs for Photoacoustic Computed Tomography With In VivoBiological Tissue Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control,65(3),465-475.
MLA Sio Hang Pun,et al."Monolithic Multiband CMUTs for Photoacoustic Computed Tomography With In VivoBiological Tissue Imaging".IEEE transactions on ultrasonics, ferroelectrics, and frequency control 65.3(2018):465-475.
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