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A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis
Chen, Zhejie1,2; Hao, Wei1,2; Gao, Caifang1; Zhou, Yangyang1; Zhang, Chen3; Zhang, Jinming3; Wang, Ruibing1; Wang, Yitao1,2; Wang, Shengpeng1,2
2022-08
Source PublicationActa Pharmaceutica Sinica B
ISSN2211-3835
Volume12Issue:8Pages:3367-3382
Abstract

With the development of synthesis technology, modified messenger RNA (mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA. IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment.

KeywordPolyphenol Mrna Il-10 Colitis Inflammatory Bowel Disease Drug Delivery Mrna Delivery Supramolecular Binding
DOI10.1016/j.apsb.2022.03.025
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000841899400002
PublisherElsivier
Scopus ID2-s2.0-85128194923
Fulltext Access
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding AuthorWang, Yitao; Wang, Shengpeng
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
2.Macau Centre for Research and Development in Chinese Medicine, University of Macau
3.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
First Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Corresponding Author AffilicationInstitute of Chinese Medical Sciences;  University of Macau
Recommended Citation
GB/T 7714
Chen, Zhejie,Hao, Wei,Gao, Caifang,et al. A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis[J]. Acta Pharmaceutica Sinica B,2022,12(8):3367-3382.
APA Chen, Zhejie,Hao, Wei,Gao, Caifang,Zhou, Yangyang,Zhang, Chen,Zhang, Jinming,Wang, Ruibing,Wang, Yitao,&Wang, Shengpeng.(2022).A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis.Acta Pharmaceutica Sinica B,12(8),3367-3382.
MLA Chen, Zhejie,et al."A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis".Acta Pharmaceutica Sinica B 12.8(2022):3367-3382.
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